Seven novel HLA alleles reflect different mechanisms involved in the evolution of HLA diversity

• Verfasst von: Adamek, Martina Maria [VerfasserIn]
• Verfasst von: Klages, Cornelia [VerfasserIn]
• Verfasst von: Bauer, Manuela [VerfasserIn]
• Verfasst von: Kudlek, Evelina [VerfasserIn]
• Verfasst von: Drechsler, Alina [VerfasserIn]
• Verfasst von: Leuser, Birte [VerfasserIn]
• Verfasst von: Scherer, Sabine [VerfasserIn]
• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Verfasst von: Tran, Thuong Hien [VerfasserIn]
• Titel: Seven novel HLA alleles reflect different mechanisms involved in the evolution of HLA diversity
• Titelzusatz: description of the new alleles and review of the literature
• Verf.angabe: Martina Adamek, Cornelia Klages, Manuela Bauer, Evelina Kudlek, Alina Drechsler, Birte Leuser, Sabine Scherer, Gerhard Opelz, Thuong Hien Tran
• Jahr: 2015
• Jahr des Originals: 2014
• Umfang: 6 S.
• Fussnoten: Available online: 11 December 2014 ; Gesehen am 23.09.2020
• Titel Quelle: Enthalten in: Human immunology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1980
• Jahr Quelle: 2015
• Band/Heft Quelle: 76(2015), 1, Seite 30-35
• ISSN Quelle: 1879-1166
• DOI: doi:10.1016/j.humimm.2014.12.007
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Gene conversion
• Sach-SW: Human leukocyte antigen
• Sach-SW: New alleles
• Sach-SW: Polymorphism
• Sach-SW: Recombination
• K10plus-PPN: 1733704876

Abstract

The human leukocyte antigen (HLA) loci are among the most polymorphic genes in the human genome. The diversity of these genes is thought to be generated by different mechanisms including point mutation, gene conversion and crossing-over. During routine HLA typing, we discovered seven novel HLA alleles which were probably generated by different evolutionary mechanisms. HLA-B*41:21, HLA-DQB1*02:10 and HLA-DQA1*01:12 likely emerged from the common alleles of their groups by point mutations, all of which caused non-synonymous amino acid substitutions. In contrast, a deletion of one nucleotide leading to a frame shift with subsequent generation of a stop codon is responsible for the appearance of a null allele, HLA-A*01:123N. Whereas HLA-B*35:231 and HLA-B*53:31 were probably products of intralocus gene conversion between HLA-B alleles, HLA-C*07:294 presumably evolved by interlocus gene conversion between an HLA-C and an HLA-B allele. Our analysis of these novel alleles illustrates the different mechanisms which may have contributed to the evolution of HLA polymorphism.