Proteins associated with SF3a60 in T. brucei

• Verfasst von: Nyambega, Benson [VerfasserIn]
• Verfasst von: Helbig, Claudia [VerfasserIn]
• Verfasst von: Masiga, Daniel K. [VerfasserIn]
• Verfasst von: Clayton, Christine [VerfasserIn]
• Verfasst von: Levin, Mariano J. [VerfasserIn]
• Titel: Proteins associated with SF3a60 in T. brucei
• Verf.angabe: Benson Nyambega, Claudia Helbig, Daniel K. Masiga, Christine Clayton, Mariano J. Levin
• E-Jahr: 2014
• Jahr: March 20, 2014
• Fussnoten: Gesehen am 25.09.2020
• Titel Quelle: Enthalten in: PLOS ONE
• Ort Quelle: San Francisco, California, US : PLOS, 2006
• Jahr Quelle: 2014
• Band/Heft Quelle: 9(2014,3) Artikel-Nummer e91956, 9 Seiten
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0091956
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Protein domains
• Sach-SW: RNA interference
• Sach-SW: RNA splicing
• Sach-SW: Saccharomyces cerevisiae
• Sach-SW: Trypanosoma
• Sach-SW: Trypanosoma brucei
• Sach-SW: Trypanosoma brucei gambiense
• Sach-SW: Yeast
• K10plus-PPN: 1733721169

Abstract

Trypanosoma brucei relies on Spliced leader trans splicing to generate functional messenger RNAs. Trans splicing joins the specialized SL exon from the SL RNA to pre-mRNAs and is mediated by the trans-spliceosome, which is made up of small nuclear ribonucleoprotein particles and non-snRNP factors. Although the trans spliceosome is essential for trypanosomatid gene expression, not all spliceosomal protein factors are known and of these, only a few are completely characterized. In this study, we have characterized the trypanosome Splicing Factor, SF3a60, the only currently annotated SF3a component.