Co-translational mechanisms of protein maturation

• Verfasst von: Gloge, Felix [VerfasserIn]
• Verfasst von: Becker, Annemarie [VerfasserIn]
• Verfasst von: Kramer, Günter [VerfasserIn]
• Verfasst von: Bukau, Bernd [VerfasserIn]
• Titel: Co-translational mechanisms of protein maturation
• Verf.angabe: Felix Gloge, Annemarie H Becker, Günter Kramer and Bernd Bukau
• Jahr: 2014
• Jahr des Originals: 2013
• Umfang: 10 S.
• Fussnoten: Available online 12th December 2013 ; Gesehen am 25.09.2020
• Titel Quelle: Enthalten in: Current opinion in structural biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1991
• Jahr Quelle: 2014
• Band/Heft Quelle: 24(2014), Seite 24-33
• DOI: doi:10.1016/j.sbi.2013.11.004
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1733722947

Abstract

Protein biogenesis integrates multiple finely regulated mechanisms, ensuring nascent polypeptide chains are correctly enzymatically processed, targeted to membranes and folded to native structure. Recent studies show that the cellular translation machinery serves as hub that coordinates the maturation events in space and time at various levels. The ribosome itself serves as docking site for a multitude of nascent chain-interacting factors. The movement of ribosomes along open reading frames is non-uniformous and includes pausing sites, which facilitates nascent chain folding and perhaps factor engagement. Here we summarize current knowledge and discuss emerging concepts underlying the critical interplay between translation and protein maturation in E. coli.