Predictors of impaired endothelial function in obstructive sleep apnea syndrome

• Verfasst von: Šiarnik, Pavel [VerfasserIn]
• Verfasst von: Čarnická, Zuzana [VerfasserIn]
• Verfasst von: Krížová, Lucia [VerfasserIn]
• Verfasst von: Wágnerová, Helena [VerfasserIn]
• Verfasst von: Šutovský, Stanislav [VerfasserIn]
• Verfasst von: Klobučníková, Katarína [VerfasserIn]
• Verfasst von: Kollár, Branislav [VerfasserIn]
• Verfasst von: Turčáni, Peter [VerfasserIn]
• Verfasst von: Sykora, Marek [VerfasserIn]
• Titel: Predictors of impaired endothelial function in obstructive sleep apnea syndrome
• Verf.angabe: Pavel Šiarnik, Zuzana Čarnická, Lucia Krížová, Helena Wágnerová, Stanislav Šutovský, Katarína Klobučníková, Branislav Kollár, Peter Turčáni, Marek Sýkora
• E-Jahr: 2014
• Jahr: 2014-05-05
• Umfang: 7 S.
• Fussnoten: Gesehen am 28.09.2020
• Titel Quelle: Enthalten in: Neuroendocrinology letters
• Ort Quelle: Munsbach : Maghira & Maas, 1997
• Jahr Quelle: 2014
• Band/Heft Quelle: 35(2014), 2, Seite 142-148
• ISSN Quelle: 2354-4716
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1733843523

Abstract

OBJECTIVES: Obstructive sleep apnea syndrome (OSA) is associated with increased cardiovascular morbidity and mortality. Endothelial dysfunction (ED), accelerated atherosclerosis and autonomic dysfunction might be the key players responsible for development of vascular diseases in patients with OSA. In a population with suspected OSA and low burden of cardiovascular risk factors, we therefore aimed to investigate the association between potential cardiovascular risk factors including OSA-specific indices, ED and autonomic activity. - METHODS: ED was investigated using reperfusion hyperaemia index (RHI). OSA was assessed using standard polysomnography, autonomic activity was assessed using baroreflex sensitivity (BRS). - RESULTS: We enrolled 31 patients (42.1±11.7 years) with OSA. Significant inverse correlation was found between RHI and apnea-hypopnea index (AHI) (r=-0.550, p=0.001) and between RHI desaturation index (r=-0.533, p=0.002). Positive correlation was found between RHI and minimal nocturnal oxygen saturation (r=0.394, p=0.028). In a multiple regression model AHI was the only significant variable to predict RHI (β=-0.522, p=0.003). We found no correlation between RHI and BRS. RHI in the population with severe OSA (AHI above 30) was significantly lower than RHI in the rest of the population (p=0.012). - CONCLUSION: AHI was the only significant independent predictor of impaired endothelial function as expressed by RHI. RHI showed no association with BRS in patients with OSA.