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Verfasst von:Wolf, Robert Christian [VerfasserIn]   i
 Depping, Malte S. [VerfasserIn]   i
 Thomann, Philipp [VerfasserIn]   i
Titel:Abnormal resting-state connectivity of motor and cognitive networks in early manifest Huntington's disease
Verf.angabe:R.C. Wolf, F. Sambataro, N. Vasic, M.S. Depping, P.A. Thomann, G.B. Landwehrmeyer, S.D. Süssmuth and M. Orth
E-Jahr:2014
Jahr:27 March 2014
Umfang:16 S.
Fussnoten:Gesehen am 29.09.2020
Titel Quelle:Enthalten in: Psychological medicine
Ort Quelle:Cambridge : Cambridge University Press, 1970
Jahr Quelle:2014
Band/Heft Quelle:44(2014), 15, Seite 3341-3356
ISSN Quelle:1469-8978
Abstract:Background. Functional magnetic resonance imaging (fMRI) of multiple neural networks during the brain’s ‘resting state’ could facilitate biomarker development in patients with Huntington’s disease (HD) and may provide new insights into the relationship between neural dysfunction and clinical symptoms. To date, however, very few studies have examined the functional integrity of multiple resting state networks (RSNs) in manifest HD, and even less is known about whether concomitant brain atrophy affects neural activity in patients. - Method. Using MRI, we investigated brain structure and RSN function in patients with early HD (n = 20) and healthy controls (n = 20). For resting-state fMRI data a group-independent component analysis identified spatiotemporally distinct patterns of motor and prefrontal RSNs of interest. We used voxel-based morphometry to assess regional brain atrophy, and ‘biological parametric mapping’ analyses to investigate the impact of atrophy on neural activity. - Results. Compared with controls, patients showed connectivity changes within distinct neural systems including lateral prefrontal, supplementary motor, thalamic, cingulate, temporal and parietal regions. In patients, supplementary motor area and cingulate cortex connectivity indices were associated with measures of motor function, whereas lateral prefrontal connectivity was associated with cognition. - Conclusions. This study provides evidence for aberrant connectivity of RSNs associated with motor function and cognition in early manifest HD when controlling for brain atrophy. This suggests clinically relevant changes of RSN activity in the presence of HD-associated cortical and subcortical structural abnormalities.
DOI:doi:10.1017/S0033291714000579
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1017/S0033291714000579
 Volltext: https://www.cambridge.org/core/product/identifier/S0033291714000579/type/journal_article
 DOI: https://doi.org/10.1017/S0033291714000579
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1733939636
Verknüpfungen:→ Zeitschrift

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