Validation of nine different prognostic grading indexes for radiosurgery of brain metastases in breast cancer patients and development of an all-encompassing prognostic tool

• Verfasst von: Weykamp, Fabian [VerfasserIn]
• Verfasst von: El-Shafie, Rami [VerfasserIn]
• Verfasst von: König, Laila [VerfasserIn]
• Verfasst von: Seidensaal, Katharina [VerfasserIn]
• Verfasst von: Forster, Tobias [VerfasserIn]
• Verfasst von: Arians, Nathalie [VerfasserIn]
• Verfasst von: Regnery, Sebastian [VerfasserIn]
• Verfasst von: Hoegen-Saßmannshausen, Philipp [VerfasserIn]
• Verfasst von: Deutsch, Thomas M. [VerfasserIn]
• Verfasst von: Schneeweiss, Andreas [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Hörner-Rieber, Juliane [VerfasserIn]
• Titel: Validation of nine different prognostic grading indexes for radiosurgery of brain metastases in breast cancer patients and development of an all-encompassing prognostic tool
• Verf.angabe: Fabian Weykamp, Rami A. El Shafie, Laila König, Katharina Seidensaal, Tobias Forster, Nathalie Arians, Sebastian Regnery, Philipp Hoegen, Thomas M. Deutsch, Andreas Schneeweiss, Jürgen Debus and Juliane Hoerner-Rieber
• E-Jahr: 2020
• Jahr: 02 September 2020
• Umfang: 15 S.
• Fussnoten: Gesehen am 30.09.2020
• Titel Quelle: Enthalten in: Frontiers in oncology
• Ort Quelle: Lausanne : Frontiers Media, 2011
• Jahr Quelle: 2020
• Band/Heft Quelle: 10(2020) Artikel-Nummer 1557, 15 Seiten
• ISSN Quelle: 2234-943X
• DOI: doi:10.3389/fonc.2020.01557
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: brain metastases
• Sach-SW: breast cancer
• Sach-SW: Breast Graded Prognostic Assessment
• Sach-SW: overall survival
• Sach-SW: prognostic grading index
• Sach-SW: Prognostic tool
• Sach-SW: Stereotactic radiosurgery
• K10plus-PPN: 1733998373
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Purpose Several prognostic indexes for overall survival (OS) after radiotherapy of brain metastases in breast cancer patients exist, but are mainly validated for whole brain radiotherapy or not specifically for breast cancer patients. To date, no such index provides information beyond mere OS. Methods We retrospectively analyzed 95 breast cancer patients treated with stereotactic radiosurgery for 203 brain metastases. Kaplan-Meier method with log-rank test was used to assess OS, local control (LC), distant cranial control (DCC) and extracranial control (EC). Cox regression was applied to detect prognostic outcome factors. A point scoring system was designed to stratify patients based on outcome. Nine established prognostic indexes were analyzed using the concordance index (c-index). Results Two out of nine analyzed prognostic indexes for OS showed a significant c-index, the breast graded prognostic assessment (bGPA; 0.631; 95% CI, 0.514 to 0.748; p=0.037) and the modified bGPA (mod-bGPA; 0.662; 95% CI, 0.547 to 0.777; p=0.010). Significant results from multivariate analysis (Karnofsky Performance Score, Her2/neu receptor status, extracranial control) were used to generate a new point system: the breast cancer stereotactic radiotherapy score (bSRS), which discriminated three significantly different prognostic groups, for LC, DCC, EC and OS, respectively. However, the c-index was only significant for OS (0.689; 95% CI, 0.577 to 0.802; p=0.003). Conclusions The new bSRS score was superior to the bGPA and the mod-bGPA scores for prognosis of OS. The bSRS is easy to use and the first tool which might also provide outcome assessment beyond mere OS. Future studies need to validate these findings.