| |  Online-Ressource |
|---|
| Verfasst von: | Stolp-Rastätter, Bettina [VerfasserIn]  |
|---|
| | Thelen, Flavian [VerfasserIn] |
|---|
| | Ficht, Xenia [VerfasserIn] |
|---|
| | Altenburger, Lukas M. [VerfasserIn] |
|---|
| | Ruef, Nora [VerfasserIn] |
|---|
| | Inavalli, V. V. G. Krishna [VerfasserIn] |
|---|
| | Germann, Philipp [VerfasserIn] |
|---|
| | Page, Nicolas [VerfasserIn] |
|---|
| | Moalli, Federica [VerfasserIn] |
|---|
| | Raimondi, Andrea [VerfasserIn] |
|---|
| | Keyser, Kirsten A. [VerfasserIn] |
|---|
| | Seyed Jafari, S. Morteza [VerfasserIn] |
|---|
| | Barone, Francesca [VerfasserIn] |
|---|
| | Dettmer, Matthias S. [VerfasserIn] |
|---|
| | Merkler, Doron [VerfasserIn] |
|---|
| | Iannacone, Matteo [VerfasserIn] |
|---|
| | Sharpe, James [VerfasserIn] |
|---|
| | Schlapbach, Christoph [VerfasserIn] |
|---|
| | Fackler, Oliver T. [VerfasserIn] |
|---|
| | Nägerl, U. Valentin [VerfasserIn] |
|---|
| | Stein, Jens V. [VerfasserIn] |
|---|
| Titel: | Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance |
|---|
| Paralleltitel: | Salivary gland macrophages and tissue-resident CD8(+) T cells cooperate for homeostatic organ surveillance |
|---|
| Verf.angabe: | Bettina Stolp, Flavian Thelen, Xenia Ficht, Lukas M. Altenburger, Nora Ruef, V.V.G. Krishna Inavalli, Philipp Germann, Nicolas Page, Federica Moalli, Andrea Raimondi, Kirsten A. Keyser, S. Morteza Seyed Jafari, Francesca Barone, Matthias S. Dettmer, Doron Merkler, Matteo Iannacone, James Sharpe, Christoph Schlapbach, Oliver T. Fackler, U. Valentin Nägerl, Jens V. Stein |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 3 April 2020 |
|---|
| Umfang: | 14 S. |
|---|
| Fussnoten: | Gesehen am 05.10.2020 ; Im Titel ist "+" hochgestellt |
|---|
| Titel Quelle: | Enthalten in: Science immunology |
|---|
| Ort Quelle: | Washington, DC : AAAS, 2016 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 5(2020), 46, Artikel-ID eaaz4371, Seite 1-14 |
|---|
| ISSN Quelle: | 2470-9468 |
|---|
| Abstract: | It is well established that tissue macrophages and tissue-resident memory CD8(+) T cells (T-RM) play important roles for pathogen sensing and rapid protection of barrier tissues. In contrast, the mechanisms by which these two cell types cooperate for homeostatic organ surveillance after clearance of infections is poorly understood. Here, we used intravital imaging to show that T-RM dynamically followed tissue macrophage topology in noninflamed murine submandibular salivary glands (SMGs). Depletion of tissue macrophages interfered with SMG T-RM motility and caused a reduction of interepithelial T cell crossing. In the absence of macrophages, SMG T-RM failed to cluster in response to local inflammatory chemokines. A detailed analysis of the SMG microarchitecture uncovered discontinuous attachment of tissue macrophages to neighboring epithelial cells, with occasional macrophage protrusions bridging adjacent acini and ducts. When dissecting the molecular mechanisms that drive homeostatic SMG T-RM motility, we found that these cells exhibit a wide range of migration modes: In addition to chemokine-and adhesion receptor-driven motility, resting SMG T-RM displayed a remarkable capacity for autonomous motility in the absence of chemoattractants and adhesive ligands. Autonomous SMG T-RM motility was mediated by friction and insertion of protrusions into gaps offered by the surrounding microenvironment. In sum, SMG T-RM display a unique continuum of migration modes, which are supported in vivo by tissue macrophages to allow homeostatic patrolling of the complex SMG architecture. |
|---|
| DOI: | doi:10.1126/sciimmunol.aaz4371 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1126/sciimmunol.aaz4371 |
|---|
| | DOI: https://doi.org/10.1126/sciimmunol.aaz4371 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | activation |
|---|
| | chemokines |
|---|
| | dendritic cells |
|---|
| | expression profiles |
|---|
| | memory |
|---|
| | migration |
|---|
| | motility |
|---|
| | networks |
|---|
| | pathways |
|---|
| | trigger |
|---|
| K10plus-PPN: | 1734657952 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance / Stolp-Rastätter, Bettina [VerfasserIn]; 3 April 2020 (Online-Ressource)
