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| Verfasst von: | Gack, Sabine [VerfasserIn]  |
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| | Vallon, Rüdiger [VerfasserIn] |
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| | Schmidt, Jörg [VerfasserIn] |
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| | Grigoriadis, Agamemnon [VerfasserIn] |
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| | Tuckermann, Jan Peter Gottfried [VerfasserIn] |
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| | Schenkel, Johannes [VerfasserIn] |
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| | Weiher, Hans [VerfasserIn] |
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| | Wagner, Erwin F. [VerfasserIn] |
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| | Angel, Peter [VerfasserIn] |
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| Titel: | Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes |
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| Verf.angabe: | Sabine Gack, Rüdiger Vallon, Jörg Schmidt, Agamemnon Grigoriadis, Jan Tuckermann, Johannes Schenkel, Hans Weiher, Erwin F. Wagner, and Peter Angel |
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| E-Jahr: | 1995 |
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| Jahr: | Juni 1995 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 07.10.2020 |
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| Titel Quelle: | Enthalten in: Cell growth & differentiation |
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| Ort Quelle: | Philadelphia, Pa. : AACR, 1990 |
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| Jahr Quelle: | 1995 |
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| Band/Heft Quelle: | 6(1995), 6, Seite 759-767 |
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| ISSN Quelle: | 1044-9523 |
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| Abstract: | We determined the expression pattern of the matrix metalloproteinase interstitial collagenase (MMP-1) during mouse embryo development using in situ hybridization and immunohistochemistry. Localized MMP-1 mRNA was first detected at 14.5 days postconceptus. The spatial and temporal expression was restricted to areas of endochondral and intramembranous bone formation, such as in the mandibula, maxilla, clavicle, scapula, in the vertebrae, and in the dorsal, but not the ventral part of the ribs. The highest levels of MMP-1 transcripts and MMP-1 protein were found in the metaphyses and diaphyses of the long bones. MMP-1 was expressed by hypertrophic chondrocytes and by osteoblastic cells localized along the newly formed bone trabeculae. No expression was detected in osteoclasts. Two other related members of the MMP family, stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10), were not expressed during days 7.5 and 16.5 of mouse embryogenesis. The tissue-specific expression of MMP-1 and the exclusive ability of interstitial collagenase to digest native collagen of types I, II, III, and X, the major components of bone, cartilage, and tendon, strongly suggests an important and specific function of this enzyme in bone development and remodeling. |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://pubmed.ncbi.nlm.nih.gov/7669731/ |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Bone and Bones |
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| | Bone Development |
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| | Cartilage |
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| | Collagenases |
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| | Embryonic and Fetal Development |
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| | Enzyme Induction |
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| | Female |
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| | Gestational Age |
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| | Hypertrophy |
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| | Male |
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| | Matrix Metalloproteinase 1 |
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| | Matrix Metalloproteinase 10 |
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| | Matrix Metalloproteinase 3 |
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| | Metalloendopeptidases |
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| | Mice |
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| | Mice, Inbred BALB C |
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| | Mice, Inbred C57BL |
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| | Osteoblasts |
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| K10plus-PPN: | 1734919833 |
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| Verknüpfungen: | → Zeitschrift |
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Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes / Gack, Sabine [VerfasserIn]; Juni 1995 (Online-Ressource)
