| |  Online-Ressource |
|---|
| Verfasst von: | Li, Hanmei [VerfasserIn]  |
|---|
| | Roxo, Mariana [VerfasserIn] |
|---|
| | Cheng, Xinlai [VerfasserIn] |
|---|
| | Zhang, Shaoxiong [VerfasserIn] |
|---|
| | Cheng, Haoran [VerfasserIn] |
|---|
| | Wink, Michael [VerfasserIn] |
|---|
| Titel: | Pro-oxidant and lifespan extension effects of caffeine and related methylxanthines in caenorhabditis elegans |
|---|
| Verf.angabe: | Hanmei Li, Mariana Roxo, Xinlai Cheng, Shaoxiong Zhang, Haoran Cheng, Michael Wink |
|---|
| E-Jahr: | 2019 |
|---|
| Jahr: | 19 January 2019 |
|---|
| Umfang: | 9 S. |
|---|
| Teil: | volume:1 |
|---|
| | year:2019 |
|---|
| | extent:9 |
|---|
| Fussnoten: | Gesehen am 09.10.2020 |
|---|
| Titel Quelle: | Enthalten in: Food chemistry: X |
|---|
| Ort Quelle: | Amsterdam : Elsevier, 2019 |
|---|
| Jahr Quelle: | 2019 |
|---|
| Band/Heft Quelle: | 1(2019) Artikel-Nummer 100005, 9 Seiten |
|---|
| ISSN Quelle: | 2590-1575 |
|---|
| Abstract: | Caffeine and related purine alkaloids are common ingredients of many stimulating drinks. Studies have shown that lower concentrations of caffeine have a protective role in aging-related disorders. However, the associated mode of action of caffeine and its related methylxanthines is still not clear. In this study, we demonstrated that caffeine and theophylline promote longevity in Caenorhabditis elegans. Lifespan studies with the wild type, DAF-16 and SKN-1 mutant strains indicated that the methylxanthines-mediated lifespan extension in C. elegans was independent of DAF-16/FOXO and SKN-1. All the tested methylxanthines could protect C. elegans against acute oxidative stress. At early stages of life, an increase of ROS (reactive oxygen species) induced the translocation of DAF-16 and SKN-1, resulting in upregulation of several antioxidant genes, for example, sod-3p::GFP, gst-4p::GFP, gcs-1p::GFP; and downregulation of hsp-16.2p::GFP. RT-PCR corroborates the upregulation of gst-4 and skn-1 genes. The expression of DAF-16 decreased although its nuclear translocation was induced. |
|---|
| DOI: | doi:10.1016/j.fochx.2019.100005 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.fochx.2019.100005 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S2590157519300070 |
|---|
| | DOI: https://doi.org/10.1016/j.fochx.2019.100005 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Caffeine |
|---|
| | DAF-16/FOXO |
|---|
| | Pro-oxidant effect |
|---|
| | SKN-1 |
|---|
| | Theobromine |
|---|
| | Theophylline |
|---|
| K10plus-PPN: | 1735249769 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Pro-oxidant and lifespan extension effects of caffeine and related methylxanthines in caenorhabditis elegans / Li, Hanmei [VerfasserIn]; 19 January 2019 (Online-Ressource)
