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Verfasst von:Strekalova, Tatyana [VerfasserIn]   i
 Spanagel, Rainer [VerfasserIn]   i
 Bartsch, Dusan [VerfasserIn]   i
 Henn, Fritz A. [VerfasserIn]   i
 Gass, Peter [VerfasserIn]   i
Titel:Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration
Verf.angabe:Tatyana Strekalova, Rainer Spanagel, Dusan Bartsch, Fritz A. Henn, and Peter Gass
E-Jahr:2004
Jahr:21 July 2004
Umfang:11 S.
Fussnoten:Gesehen am 13.010.2020
Titel Quelle:Enthalten in: Neuropsychopharmacology
Ort Quelle:London : Springer Nature, 1993
Jahr Quelle:2004
Band/Heft Quelle:29(2004), 11, Seite 2007-2017
ISSN Quelle:1740-634X
Abstract:In order to develop a model for a depression-like syndrome in mice, we subjected male C57BL/6 mice to a 4-week-long chronic stress procedure, consisting of rat exposure, restraint stress, and tail suspension. This protocol resulted in a strong decrease in sucrose preference, a putative indicator of anhedonia in rodents. Interestingly, predisposition for stress-induced anhedonia was indicated by submissive behavior in a resident-intruder test. In contrast, most mice with nonsubmissive behavior did not develop a decrease in sucrose preference and were regarded as nonanhedonic. These animals were used as an internal control for stress-induced behavioral features not associated with the anhedonic state, since they were exposed to the same stressors as the anhedonic mice. Using a battery of behavioral tests after termination of the stress procedure, we found that anhedonia, but not chronic stress per se, is associated with key analogues of depressive symptoms, such as increased floating during forced swimming and decreased exploration of novelty. On the other hand, increased anxiety, altered locomotor activity, and loss of body weight were consequences of chronic stress, which occurred independently from anhedonia. Thus, behavioral correlates of stress-induced anhedonia and of chronic stress alone can be separated in the present model.
DOI:doi:10.1038/sj.npp.1300532
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/sj.npp.1300532
 Volltext: https://www.nature.com/articles/1300532
 DOI: https://doi.org/10.1038/sj.npp.1300532
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Animals
 Depression
 Exploratory Behavior
 Immobilization
 Male
 Mice
 Mice, Inbred C57BL
 Rats
 Stress, Physiological
 Swimming
K10plus-PPN:1735420034
Verknüpfungen:→ Zeitschrift

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