| |  Online-Ressource |
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| Verfasst von: | Hayden, Steven C. [VerfasserIn]  |
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| | Bryant, Jonathan [VerfasserIn] |
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| | Mackey, Megan A. [VerfasserIn] |
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| | Höfer, Katharina [VerfasserIn] |
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| | Lindner, Benjamin [VerfasserIn] |
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| | Nguyen, Vanessa P. [VerfasserIn] |
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| | Jäschke, Andres [VerfasserIn] |
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| | Bunz, Uwe H. F. [VerfasserIn] |
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| Titel: | Antimicrobial activity of water-soluble triazole phenazine clickamers against E. coli |
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| Verf.angabe: | Steven C. Hayden, Jonathan J. Bryant, Megan A. Mackey, Katharina Höfer, Benjamin D. Lindner, Vanessa P. Nguyen, Andres Jäschke, and Uwe H.F. Bunz |
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| Jahr: | 2014 |
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| Umfang: | 5 S. |
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| Fussnoten: | Published online on December 11, 2013 ; Gesehen am 13.10.2020 |
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| Titel Quelle: | Enthalten in: Chemistry - a European journal |
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| Ort Quelle: | Weinheim : Wiley-VCH, 1995 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 20(2014), 3, Seite 719-723 |
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| ISSN Quelle: | 1521-3765 |
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| Abstract: | The antimicrobial potency of phenazine derivatives is attenuated by their inherently hydrophobic nature, complicating their use as antibiotic drugs. We have analyzed the cytotoxicity and mode of action of water-soluble bis-triazolyl phenazines against E. coli and a human epithelial (HaCat) cell line. We observed complete inhibition of bacterial growth over concentration ranges that do not affect the viability of human epithelial cells. Confocal fluorescence microscopy revealed a high degree of interaction between the phenazine compounds and E. coli, as well as evidence of membrane damage in phenazine-treated E. coli. Additional data suggests that the potency of these particular water-soluble phenazine compounds does not result from the production of reactive oxygen species, but rather from cytotoxic interference with metabolic electron-transfer cascades. |
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| DOI: | doi:10.1002/chem.201303353 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/chem.201303353 |
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| | Volltext: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201303353 |
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| | DOI: https://doi.org/10.1002/chem.201303353 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antimicrobial |
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| | Escherichia coli |
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| | phenazines |
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| | redox cycling |
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| | water soluble |
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| K10plus-PPN: | 1735426725 |
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| Verknüpfungen: | → Zeitschrift |
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Antimicrobial activity of water-soluble triazole phenazine clickamers against E. coli / Hayden, Steven C. [VerfasserIn]; 2014 (Online-Ressource)
