| Online-Ressource |
Verfasst von: | Gaub, Aline [VerfasserIn]  |
| Sheikh, Bilal N. [VerfasserIn]  |
| Basilicata, M. Felicia [VerfasserIn]  |
| Vincent, Marie [VerfasserIn]  |
| Nizon, Mathilde [VerfasserIn]  |
| Colson, Cindy [VerfasserIn]  |
| Bird, Matthew J. [VerfasserIn]  |
| Bradner, James E. [VerfasserIn]  |
| Thevenon, Julien [VerfasserIn]  |
| Boutros, Michael [VerfasserIn]  |
| Akhtar, Asifa [VerfasserIn]  |
Titel: | Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation |
Verf.angabe: | Aline Gaub, Bilal N. Sheikh, M. Felicia Basilicata, Marie Vincent, Mathilde Nizon, Cindy Colson, Matthew J. Bird, James E. Bradner, Julien Thevenon, Michael Boutros & Asifa Akhtar |
E-Jahr: | 2020 |
Jahr: | May 7, 2020 |
Umfang: | 17 S. |
Fussnoten: | Gesehen am 13.10.2020 |
Titel Quelle: | Enthalten in: Nature Communications |
Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 11(2020) Artikel-Nummer 2243, 17 Seiten |
ISSN Quelle: | 2041-1723 |
Abstract: | Cells rely on a diverse repertoire of genes for maintaining homeostasis, but the transcriptional networks underlying their expression remain poorly understood. The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator. It is essential in Drosophila, and haploinsufficiency of the human KANSL1 subunit results in the Koolen-de Vries syndrome. Here, we perform a genome-wide RNAi screen and identify the BET protein BRD4 as an evolutionary conserved co-factor of the NSL complex. Using Drosophila and mouse embryonic stem cells, we characterise a recruitment hierarchy, where NSL-deposited histone acetylation enables BRD4 recruitment for transcription of constitutively active genes. Transcriptome analyses in Koolen-de Vries patient-derived fibroblasts reveals perturbations with a cellular homeostasis signature that are evoked by the NSL complex/BRD4 axis. We propose that BRD4 represents a conserved bridge between the NSL complex and transcription activation, and provide a new perspective in the understanding of their functions in healthy and diseased states. |
DOI: | doi:10.1038/s41467-020-16103-0 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-020-16103-0 |
| Volltext: https://www.nature.com/articles/s41467-020-16103-0 |
| DOI: https://doi.org/10.1038/s41467-020-16103-0 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1735462888 |
Verknüpfungen: | → Zeitschrift |
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation / Gaub, Aline [VerfasserIn]; May 7, 2020 (Online-Ressource)