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| Verfasst von: | Gaub, Aline [VerfasserIn]  |
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| | Sheikh, Bilal N. [VerfasserIn] |
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| | Basilicata, M. Felicia [VerfasserIn] |
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| | Vincent, Marie [VerfasserIn] |
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| | Nizon, Mathilde [VerfasserIn] |
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| | Colson, Cindy [VerfasserIn] |
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| | Bird, Matthew J. [VerfasserIn] |
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| | Bradner, James E. [VerfasserIn] |
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| | Thevenon, Julien [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| | Akhtar, Asifa [VerfasserIn] |
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| Titel: | Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation |
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| Verf.angabe: | Aline Gaub, Bilal N. Sheikh, M. Felicia Basilicata, Marie Vincent, Mathilde Nizon, Cindy Colson, Matthew J. Bird, James E. Bradner, Julien Thevenon, Michael Boutros & Asifa Akhtar |
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| E-Jahr: | 2020 |
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| Jahr: | May 7, 2020 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 13.10.2020 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 11(2020) Artikel-Nummer 2243, 17 Seiten |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Cells rely on a diverse repertoire of genes for maintaining homeostasis, but the transcriptional networks underlying their expression remain poorly understood. The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator. It is essential in Drosophila, and haploinsufficiency of the human KANSL1 subunit results in the Koolen-de Vries syndrome. Here, we perform a genome-wide RNAi screen and identify the BET protein BRD4 as an evolutionary conserved co-factor of the NSL complex. Using Drosophila and mouse embryonic stem cells, we characterise a recruitment hierarchy, where NSL-deposited histone acetylation enables BRD4 recruitment for transcription of constitutively active genes. Transcriptome analyses in Koolen-de Vries patient-derived fibroblasts reveals perturbations with a cellular homeostasis signature that are evoked by the NSL complex/BRD4 axis. We propose that BRD4 represents a conserved bridge between the NSL complex and transcription activation, and provide a new perspective in the understanding of their functions in healthy and diseased states. |
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| DOI: | doi:10.1038/s41467-020-16103-0 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-020-16103-0 |
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| | Volltext: https://www.nature.com/articles/s41467-020-16103-0 |
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| | DOI: https://doi.org/10.1038/s41467-020-16103-0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1735462888 |
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| Verknüpfungen: | → Zeitschrift |
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Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation / Gaub, Aline [VerfasserIn]; May 7, 2020 (Online-Ressource)
