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Verfasst von:Roxo, Mariana [VerfasserIn]   i
 Peixoto, Herbenya [VerfasserIn]   i
 Link, Pille [VerfasserIn]   i
 Lima, Emerson [VerfasserIn]   i
 Wink, Michael [VerfasserIn]   i
Titel:Piquiá Shells (Caryocar villosum)
Titelzusatz:a fruit by-product with antioxidant and antiaging properties in caenorhabditis elegans
Verf.angabe:Mariana Roxo, Herbenya Peixoto, Pille Wetterauer, Emerson Lima and Michael Wink
E-Jahr:2020
Jahr:25 Aug 2020
Umfang:19 S.
Teil:year:2020
 extent:19
Fussnoten:Gesehen am 14.10.2020
Titel Quelle:Enthalten in: Oxidative medicine and cellular longevity
Ort Quelle:Austin, Tex. : Landes Bioscience, 2008
Jahr Quelle:2020
Band/Heft Quelle:(2020) Artikel-Nummer 7590707, 19 Seiten
ISSN Quelle:1942-0994
Abstract:In a context of rising demand for sustainable antiaging interventions, fruit processing by-products are a promising source of bioactive compounds for the production of antiaging dietary supplements. Piquiá (Caryocar villosum) is a native Amazonian fruit consisting of 65% nonedible shells. In the present study, the phytochemical profile of a hydroalcoholic extract of piquiá shells (CV) was characterized by LC-MS/MS analysis. Its antioxidant and antiaging activities were investigated using the nematode Caenorhabditis elegans as an in vivo model. CV is mainly composed by hydrolysable tannins and triterpenoid saponins. The extract enhanced stress resistance of wild-type and mutant worms by reducing the intracellular levels of reactive oxygen species (ROS) and by increasing their survival against a lethal dose of the prooxidant juglone. These effects involved the upregulation of sod-3 and downregulation of gst-4 and hsp-16.2, studied through the GFP fluorescent reporter intensity and at the transcriptional level by qRT-PCR analysis. CV extended the lifespan of wild-type worms in a DAF-16/FoxO- and SKN-1/Nrf-dependent manner. Taken together, our findings indicate piquiá shells as potential candidates for nutraceutical applications. Further studies are needed to validate the relevance of our findings to antiaging interventions in humans.
DOI:doi:10.1155/2020/7590707
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://www.hindawi.com/journals/omcl/2020/7590707/
 DOI: https://doi.org/10.1155/2020/7590707
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1735502448
Verknüpfungen:→ Zeitschrift

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