Microdomain calcium fluctuations as a colored noise process

• Verfasst von: Wegner, Frederic von [VerfasserIn]
• Verfasst von: Wieder, Nicolas Wolfgang [VerfasserIn]
• Verfasst von: Fink, Rainer [VerfasserIn]
• Titel: Microdomain calcium fluctuations as a colored noise process
• Verf.angabe: Frederic von Wegner, Nicolas Wieder and Rainer H.A. Fink
• E-Jahr: 2014
• Jahr: 03 November 2014
• Fussnoten: Gesehen am 14.10.2020
• Titel Quelle: Enthalten in: Frontiers in genetics
• Ort Quelle: Lausanne : Frontiers Media, 2010
• Jahr Quelle: 2014
• Band/Heft Quelle: 5(2014) Artikel-Nummer 376, 13 Seiten
• ISSN Quelle: 1664-8021
• DOI: doi:10.3389/fgene.2014.00376
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: calcium microdomains
• Sach-SW: Calcium Signaling
• Sach-SW: Chemical Langevin equation
• Sach-SW: Gillespie Algorithm
• Sach-SW: molecular noise
• Sach-SW: Ornstein-Uhlenbeck process
• Sach-SW: Stochastic simulation
• K10plus-PPN: 1735544043

Abstract

Calcium ions play a key role in subcellular signaling as localized transients of the intracellular calcium concentration modify the activity of ion channels, enzymes and transcription factors, among others. The intracellular calcium concentration is inherently noisy, as diffusion, the transient binding to and dissociation from buffer molecules and stochastically gating calcium channels contribute to the fluctuations of the local copy number of Ca2+ ions. We study the properties of the fluctuating calcium concentration in sub-femtoliter volumes using an exact stochastic simulation algorithm and approximations to the exact stochastic solution.