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| Verfasst von: | Teipel, Stefan [VerfasserIn]  |
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| | Reuter, Sigrid [VerfasserIn] |
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| | Stieltjes, Bram [VerfasserIn] |
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| | Acosta-Cabronero, Julio [VerfasserIn] |
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| | Ernemann, Ulrike [VerfasserIn] |
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| | Fellgiebel, Andreas [VerfasserIn] |
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| | Filippi, Massimo [VerfasserIn] |
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| | Frisoni, Giovanni [VerfasserIn] |
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| | Hentschel, Frank [VerfasserIn] |
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| | Jessen, Frank [VerfasserIn] |
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| | Klöppel, Stefan [VerfasserIn] |
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| | Meindl, Thomas [VerfasserIn] |
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| | Pouwels, Petra J. W. [VerfasserIn] |
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| | Hauenstein, Karl-Heinz [VerfasserIn] |
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| | Hampel, Harald [VerfasserIn] |
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| Titel: | Multicenter stability of diffusion tensor imaging measures |
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| Titelzusatz: | A European clinical and physical phantom study |
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| Verf.angabe: | Stefan J. Teipel, Sigrid Reuter, Bram Stieltjes, Julio Acosta-Cabronero, Ulrike Ernemann, Andreas Fellgiebel, Massimo Filippi, Giovanni Frisoni, Frank Hentschel, Frank Jessen, Stefan Klöppel, Thomas Meindl, Petra J. W. Pouwels, Karl-Heinz Hauenstein, Harald Hampel |
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| E-Jahr: | 2011 |
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| Jahr: | 9 November 2011 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 15.10.2020 |
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| Titel Quelle: | Enthalten in: Psychiatry research |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1979 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 194(2011), 3, Seite 363-371 |
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| ISSN Quelle: | 1872-7123 |
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| Abstract: | Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans in a group of 26 patients with clinically probable Alzheimer's disease (AD) and 12 healthy elderly controls at one single center. We determined the variability of fractional anisotropy (FA) measures using manually placed regions of interest as well as automated tract based spatial statistics and deformation based analysis. The coefficient of variation (CV) of FA was 6.9% for the physical phantom data. The mean CV across the multicenter brain scans was 14% for tract based statistics, and 29% for deformation based analysis. The degree of variation was higher in less organized fiber tracts. Our findings suggest that a clinical and physical phantom study involving more than two scanners is indispensable to detect potential sources of bias and to reliably estimate effect size in multicenter diagnostic trials using DTI. |
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| DOI: | doi:10.1016/j.pscychresns.2011.05.012 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.pscychresns.2011.05.012 |
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| | Verlag: http://www.sciencedirect.com/science/article/pii/S0925492711002046 |
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| | DOI: https://doi.org/10.1016/j.pscychresns.2011.05.012 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Multicenter stability of diffusion tensor imaging measures. - 2011 |
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| Sach-SW: | Alzheimer's disease |
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| | Diffusion tensor imaging |
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| | Early diagnosis |
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| | Effect size estimation |
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| | Multicenter studies |
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| | Physical phantom |
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| K10plus-PPN: | 1735635766 |
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| Verknüpfungen: | → Zeitschrift |
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Multicenter stability of diffusion tensor imaging measures / Teipel, Stefan [VerfasserIn]; 9 November 2011 (Online-Ressource)
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