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Verfasst von:Navolan, Dan Bogdan [VerfasserIn]   i
 Stoian, Dana Liana [VerfasserIn]   i
 Bohiltea, Roxana Elena [VerfasserIn]   i
 Crainiceanu, Zorin [VerfasserIn]   i
 Craina, Marius Lucian [VerfasserIn]   i
 Cretu, Octavian [VerfasserIn]   i
 Timar, Bogdan [VerfasserIn]   i
 Vladareanu, Radu [VerfasserIn]   i
 Terness, Peter [VerfasserIn]   i
 Bürger, Friederike [VerfasserIn]   i
 Nemescu, Dragos [VerfasserIn]   i
Titel:Comparison of early pregnancy serum concentration of neopterin, neopterin/creatinine ratio, C‑reactive protein, and chitotriosidase, in pregnant women with birth at term and spontaneous preterm birth
Verf.angabe:Dan Bogdan Navolan, Dana Liana Stoian, Roxana Elena Bohiltea, Zorin Crainiceanu, Marius Lucian Craina, Octavian Cretu, Bogdan Timar, Radu Vladareanu, Peter Terness, Friederike Būrger and Dragos Nemescu
E-Jahr:2020
Jahr:May 21, 2020
Umfang:6 S.
Fussnoten:Gesehen am 15.10.2020
Titel Quelle:Enthalten in: Experimental and Therapeutic Medicine
Ort Quelle:Athens : Spandidos Publ., 2010
Jahr Quelle:2020
Band/Heft Quelle:20(2020), 3, Seite 2449-2454
ISSN Quelle:1792-1015
Abstract:Inflammatory mechanisms are involved in achieving a normal pregnancy and in the development of certain pregnancy complications. These changes are more intense in pregnant women that suffer of pregnancy complications, such as spontaneous preterm birth (SPB). This study compared the course of inflammatory markers (IM) [neopterin (Neo), neopterin/creatinine ratio (Neo/Cre), C‑reactive protein (CRP), and chitotriosidase (Chito)] serum concentration in the early pregnancy of women with birth at term (BT) and preterm birth (PB). IM concentration was measured in 90 sera sampled from 45 pregnancies with BT and 30 sera from 15 pregnancies with PB. Two sera were sampled from each pregnant woman: one in the first trimester and another one in the second trimester. Early pregnancy IM concentration showed a direct correlation with gestational age: Neo (rho=0.262, P=0.004), Neo/Cre (rho=0.372, P<0.001), CRP (rho=0.187, P=0.041), and Chito (rho=0.039, P=0.66). The correlation was present in both categories of patients with BT and PB. Patients with PB before 34 week of pregnancy (wp) and 32 wp showed higher Neo and Neo/Cre concentration than BT patients. A significant association was found between the risk of PB before 34 wp, PB before 32 wp, and Neo concentration (PB <34 wp: odds ratio (OR) =5.13, P=0.035) (PB <32 wp: OR=8.2, P=0.020) and, respectively, Neo/Cre concentration (PB <34 wp: OR=5.29, P=0.015) (PB <32 wp: OR=9.25, P=0.006). No association between CRP or Chito and PB age was found. IM concentration correlates with the gestational age at the time of blood sampling. Increased Neo and Neo/Cre concentration are associated with PB. Further studies are needed to evaluate the usefulness of these markers in clinical practice.
DOI:doi:10.3892/etm.2020.8784
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3892/etm.2020.8784
 Volltext: http://www.spandidos-publications.com/10.3892/etm.2020.8784/abstract
 DOI: https://doi.org/10.3892/etm.2020.8784
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1735692026
Verknüpfungen:→ Zeitschrift

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