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Verfasst von:Hofmann, Nina [VerfasserIn]   i
 Steuer, Christian [VerfasserIn]   i
 Voß, Andreas [VerfasserIn]   i
 Erbel, Christian [VerfasserIn]   i
 Celik, Sultan [VerfasserIn]   i
 Dösch, Andreas [VerfasserIn]   i
 Ehlermann, Philipp [VerfasserIn]   i
 Giannitsis, Evangelos [VerfasserIn]   i
 Buß, Sebastian Johannes [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
 Korosoglou, Grigorios [VerfasserIn]   i
Titel:Comprehensive bio-imaging using myocardial perfusion reserve index during cardiac magnetic resonance imaging and high-sensitive troponin T for the prediction of outcomes in heart transplant recipients
Verf.angabe:N. P. Hofmann, C. Steuer, A. Voss, C. Erbel, S. Celik, A. Doesch, P. Ehlermann, E. Giannitsis, S. J. Buss, H. A. Katus and G. Korosoglou
E-Jahr:2014
Jahr:07 October 2014
Umfang:10 S.
Fussnoten:Gesehen am 16.10.2020
Titel Quelle:Enthalten in: American journal of transplantation
Ort Quelle:[Amsterdam] : Elsevier, 2001
Jahr Quelle:2014
Band/Heft Quelle:14(2014), 11, Seite 2607-2616
ISSN Quelle:1600-6143
Abstract:We sought to determine the ability of quantitative myocardial perfusion reserve index (MPRI) by cardiac magnetic resonance (CMR) and high-sensitive troponin T (hsTnT) for the prediction of cardiac allograft vasculopathy (CAV) and cardiac outcomes in heart transplant (HT) recipients. In 108 consecutive HT recipients (organ age 4.1 ± 4.7 years, 25 [23%] with diabetes mellitus) who underwent cardiac catheterization, CAV grade by International Society for Heart & Lung Transplantation (ISHLT) criteria, MPRI, late gadolinium enhancement (LGE) and hsTnT values were obtained. Outcome data including cardiac death and urgent revascularization (“hard cardiac events”) and revascularization procedures were prospectively collected. During a follow-up duration of 4.2 ± 1.4 years, seven patients experienced hard cardiac events and 11 patients underwent elective revascularization procedures. By multivariable analysis, hsTnT and MPRI both independently predicted cardiac events, surpassing the value of LGE and CAV by ISHLT criteria. Furthermore, hsTnT and MPRI provided complementary value. Thus, patients with high hsTnT and low MPRI showed the highest rates of cardiac events (annual event rate = 14.5%), while those with low hsTnT and high MPRI exhibited excellent outcomes (annual event rate = 0%). In conclusion, comprehensive “bio-imaging” using hsTnT, as a marker of myocardial microinjury, and CMR, as a marker of microvascular integrity and myocardial damage by LGE, may aid personalized risk-stratification in HT recipients.
DOI:doi:10.1111/ajt.12924
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1111/ajt.12924
 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.12924
 DOI: https://doi.org/10.1111/ajt.12924
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biomarker
 cardiovascular disease
 clinical research/practice
 heart transplantation/cardiology
K10plus-PPN:1735762512
Verknüpfungen:→ Zeitschrift

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