PRDM15 is associated with risk of chronic obstructive pulmonary disease in a rural population in Chile

• Verfasst von: Hosgood, Howard Dean [VerfasserIn]
• Verfasst von: Díaz-Peña, Roberto [VerfasserIn]
• Verfasst von: Blansky, Deanna [VerfasserIn]
• Verfasst von: Jaime, Sergio [VerfasserIn]
• Verfasst von: Parra, Viviana [VerfasserIn]
• Verfasst von: Boekstegers, Felix [VerfasserIn]
• Verfasst von: Lorenzo Bermejo, Justo [VerfasserIn]
• Verfasst von: García-Valero, José [VerfasserIn]
• Verfasst von: Montes, Juan F. [VerfasserIn]
• Verfasst von: Valdivia, Gonzalo [VerfasserIn]
• Verfasst von: Miravitlles, Marc [VerfasserIn]
• Verfasst von: Agustí, Àlvar [VerfasserIn]
• Verfasst von: Silva, Rafael S. [VerfasserIn]
• Verfasst von: Olloquequi, Jordi [VerfasserIn]
• Titel: PRDM15 is associated with risk of chronic obstructive pulmonary disease in a rural population in Chile
• Verf.angabe: H. Dean Hosgood III, Roberto Díaz-Peña, Deanna Blansky, Sergio Jaime, Viviana Parra, Felix Boekstegers, Justo Lorenzo Bermejo, José García-Valero, Juan F. Montes, Gonzalo Valdivia, Marc Miravitlles, Àlvar Agustí, Rafael S. Silva, Jordi Olloquequi
• E-Jahr: 2020
• Jahr: April 2020
• Umfang: 9 S.
• Fussnoten: Gesehen am 19.10.2020
• Titel Quelle: Enthalten in: Respiration
• Ort Quelle: Basel : Karger, 1968
• Jahr Quelle: 2020
• Band/Heft Quelle: 99(2020), 4, Seite 307-315
• ISSN Quelle: 1423-0356
• DOI: doi:10.1159/000506649
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1735937045

Abstract

<b><i>Background:</i></b> Genome-wide association studies (GWAS) have accelerated our understanding of the genetic underpinnings of chronic obstructive pulmonary disease (COPD); however, GWAS populations have typically consisted of European descent, with ∼1% of Latin American ancestry. <b><i>Objective:</i></b> To overcome this limitation, we conducted a GWAS in a rural Chilean population with increased COPD risk to investigate genetic variation of COPD risk in this understudied minority population. <b><i>Method:</i></b> We carried out a case-control study of 214 COPD patients (defined by the GOLD criteria) and 193 healthy controls in Talca, Chile. DNA was extracted from venous blood and genotyped on the Illumina Global Screening Array (<i>n</i> = 754,159 markers). After exclusion based on Hardy-Weinberg equilibrium (<i>p</i> ≤ 0.001), call rates (&#x3c;95%), and minor allele frequencies (&#x3c;0.5%) in controls, 455,564 markers were available for logistic regression. <b><i>Results:</i></b> <i>PRDM15</i> rs1054761 C allele (<i>p</i> = 2.22 × 10^-7) was associated with decreased COPD risk. Three <i>PRDM15</i> SNPs located on chromosome 21 were significantly associated with COPD risk (<i>p</i> &#x3c; 10^-6). Two of these SNPs, rs1054761 and rs4075967, were located on a noncoding transcript variant region of the gene. <b><i>Conclusion:</i></b> PRDM15 overexpression may play a role in the B-cell dysregulation in COPD pathogenesis. To the best of our knowledge, the association between <i>PRDM15</i> and COPD risk was not previously found in GWAS studies in largely European populations, highlighting the importance of investigating novel variants associated with COPD risk among ethnically diverse populations.