Bis (Aspirinato) Zinc (II) complex successfully inhibits carotid arterial neointima formation after balloon-injury in rats

• Verfasst von: Hegedüs, Péter [VerfasserIn]
• Verfasst von: Korkmaz-İçöz, Sevil [VerfasserIn]
• Verfasst von: Schmidt, Harald [VerfasserIn]
• Verfasst von: Karck, Matthias [VerfasserIn]
• Verfasst von: Szabó, Gábor [VerfasserIn]
• Titel: Bis (Aspirinato) Zinc (II) complex successfully inhibits carotid arterial neointima formation after balloon-injury in rats
• Verf.angabe: Péter Hegedűs, Sevil Korkmaz, Tamás Radovits, Harald Schmidt, Shiliang Li, Yutaka Yoshikawa, Hiroyuki Yasui, Béla Merkely, Matthias Karck, Gábor Szabó
• E-Jahr: 2014
• Jahr: 17 August 2014
• Umfang: 7 S.
• Fussnoten: Gesehen am 20.10.2020
• Titel Quelle: Enthalten in: Cardiovascular drugs and therapy
• Ort Quelle: Dordrecht [u.a.] : Springer Science + Business Media B.V, 1987
• Jahr Quelle: 2014
• Band/Heft Quelle: 28(2014), 6, Seite 533-539
• ISSN Quelle: 1573-7241
• DOI: doi:10.1007/s10557-014-6549-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1736035282

Abstract

Purpose: Neointima formation following angioplasty is a serious consequence of endothelial damage in arteries. Inflammatory mediators and lack of endothelial regulatory mechanisms lead to migration and proliferation of smooth-muscle cells and thus to restenosis. This study examines the effect of the novel bis (aspirinato) zinc (II) complex on neointima formation in a rat model of carotid balloon-injury. Methods: Rats underwent balloon-injury of the right common carotid artery, then received PEG400 vehicle (untreated-group), acetylsalicylic-acid (ASA-group), zinc-chloride (Zn-group) and bis (aspirinato) zinc (II) complex (Zn(ASA) 2-group) orally for 18 consecutive days. From harvested carotid arteries, histology, immunohistochemistry and mRNA expression analysis were performed. Results: Compared to the untreated-group, Zn (ASA) 2-treatment significantly lowered stenosis ratio (54.0 ± 5.8 % to 25.5 ± 3.9 %) and reduced neointima/media ratio (1.5 ± 0.2 to 0.5 ± 0.1). Significantly higher alpha smooth muscle actin mRNA and protein expression were measured after Zn (ASA)2 and Zn-treatment in comparison with the untreated and ASA-groups while the expression of matrix-metalloproteinase-9 was significantly higher in these groups compared to Zn (ASA)2. The presence of collagen in media was significantly decreased in all treated groups. mRNA expressions of nuclear factor kappa-b, transforming growth-factor-β and proliferating cell nuclear antigen were significantly down-regulated, whereas a20 was up-regulated by Zn (ASA)2 treatment compared to the untreated and ASA-groups. Conclusion: This study proves the effectivity of the novel bis (aspirinato) zinc complex in reducing neointima formation and restenosis after balloon-injury and supports the hypothesis that inhibition of smooth-muscle transformation/proliferation plays a key role in the prevention of restenosis.