Direct 17O MRI with partial volume correction

• Verfasst von: Hoffmann, Stefan Heinrich [VerfasserIn]
• Verfasst von: Radbruch, Alexander [VerfasserIn]
• Verfasst von: Bock, Michael [VerfasserIn]
• Verfasst von: Nagel, Armin Michael [VerfasserIn]
• Titel: Direct 17O MRI with partial volume correction
• Titelzusatz: first experiences in a glioblastoma patient
• Verf.angabe: Stefan H. Hoffmann, Alexander Radbruch, Michael Bock, Wolfhard Semmler, Armin M. Nagel
• E-Jahr: 2014
• Jahr: 01 April 2014
• Umfang: 9 S.
• Fussnoten: Gesehen am 21.10.2020 ; Im Titel ist die Zahl "17" hochgestellt
• Titel Quelle: Enthalten in: Magnetic resonance materials in physics, biology and medicine
• Ort Quelle: Heidelberg : Springer, 1993
• Jahr Quelle: 2014
• Band/Heft Quelle: 27(2014), 6, Seite 579-587
• ISSN Quelle: 1352-8661
• DOI: doi:10.1007/s10334-014-0441-8
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1736075292

Abstract

In tumor cells the energy production is shifted from aerobic to anaerobic metabolization of glucose, which makes the cerebral metabolic rate of oxygen consumption (CMRO2) a diagnostic parameter for tissue viability. Direct oxygen-17 (17O) MRI during inhalation of 17O gas allows for a non-invasive determination of the CMRO2. However, the low spatial resolution and the fast transverse relaxation of 17O lead to partial volume effects that severely bias the quantification of signal intensities. The aim of this work was to determine the CMRO2 in a tumor patient by 17O MRI in combination with a partial volume correction (PVC) scheme.