| |  Online-Ressource |
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| Verfasst von: | Yu, Leixiao [VerfasserIn]  |
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| | Hou, Yong [VerfasserIn] |
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| | Xie, Wenyan [VerfasserIn] |
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| | Camacho, Jose Luis Cuellar [VerfasserIn] |
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| | Cheng, Chong [VerfasserIn] |
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| | Holle, Andrew W. [VerfasserIn] |
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| | Young, Jennifer [VerfasserIn] |
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| | Trappmann, Britta [VerfasserIn] |
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| | Zhao, Weifeng [VerfasserIn] |
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| | Melzig, Matthias F. [VerfasserIn] |
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| | Cavalcanti-Adam, Elisabetta A. [VerfasserIn] |
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| | Zhao, Changsheng [VerfasserIn] |
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| | Spatz, Joachim P. [VerfasserIn] |
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| | Wei, Qiang [VerfasserIn] |
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| | Haag, Rainer [VerfasserIn] |
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| Titel: | Ligand diffusion enables force-independent cell adhesion via activating α5β1 integrin and initiating Rac and RhoA signaling |
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| Verf.angabe: | Leixiao Yu, Yong Hou, Wenyan Xie, Jose Luis Cuellar Camacho, Chong Cheng, Andrew Holle, Jennifer Young, Britta Trappmann, Weifeng Zhao, Matthias F. Melzig, Elisabetta A. Cavalcanti‐Adam, Changsheng Zhao, Joachim P. Spatz, Qiang Wei, and Rainer Haag |
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| E-Jahr: | 2020 |
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| Jahr: | 14 June 2020 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 21.10.2020 |
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| Titel Quelle: | Enthalten in: Advanced materials |
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| Ort Quelle: | Weinheim : Wiley-VCH, 1989 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 32(2020,29) Artikel-Nummer 2002566, 12 Seiten |
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| ISSN Quelle: | 1521-4095 |
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| Abstract: | Cells reside in a dynamic microenvironment in which adhesive ligand availability, density, and diffusivity are key factors regulating cellular behavior. Here, the cellular response to integrin-binding ligand dynamics by directly controlling ligand diffusivity via tunable ligand-surface interactions is investigated. Interestingly, cell spread on the surfaces with fast ligand diffusion is independent of myosin-based force generation. Fast ligand diffusion enhances α5β1 but not αvβ3 integrin activation and initiates Rac and RhoA but not ROCK signaling, resulting in lamellipodium-based fast cell spreading. Meanwhile, on surfaces with immobile ligands, αvβ3 and α5β1 integrins synergistically initiate intracellular-force-based canonical mechanotransduction pathways to enhance cell adhesion and osteogenic differentiation of stem cells. These results indicate the presence of heretofore-unrecognized pathways, distinct from canonical actomyosin-driven mechanisms, that are capable of promoting cell adhesion. |
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| DOI: | doi:10.1002/adma.202002566 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/adma.202002566 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202002566 |
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| | DOI: https://doi.org/10.1002/adma.202002566 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adhesive ligands |
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| | biointerfaces |
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| | cell adhesion |
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| | mechanotransduction |
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| | polymer coatings |
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| K10plus-PPN: | 173608237X |
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| Verknüpfungen: | → Zeitschrift |
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Ligand diffusion enables force-independent cell adhesion via activating α5β1 integrin and initiating Rac and RhoA signaling / Yu, Leixiao [VerfasserIn]; 14 June 2020 (Online-Ressource)
