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Verfasst von:Koczulla, Andreas Rembert [VerfasserIn]   i
 Kahn, Nicolas [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Kreuter, Michael [VerfasserIn]   i
Titel:Effects of vibration training in interstitial lung diseases
Titelzusatz:a randomized controlled trial
Verf.angabe:Andreas Rembert Koczulla, Tobias Boeselt, Janina Koelpin, Fabian Kaufhold, Martina Veith, Christoph Nell, Inga Jarosch, Marc Spielmanns, Peter Alter, Christian Kähler, Timm Greulich, Claus F. Vogelmeier, Rainer Glöckl, Tessa Schneeberger, Klaus Kenn, Nicolas Carlos Kahn, Felix J. F. Herth, Michael Kreuter
E-Jahr:2020
Jahr:August 19, 2020
Umfang:9 S.
Teil:volume:99
 year:2020
 number:8
 pages:658-666
 extent:9
Fussnoten:Gesehen am 21.10.2020
Titel Quelle:Enthalten in: Respiration
Ort Quelle:Basel : Karger, 1944
Jahr Quelle:2020
Band/Heft Quelle:99(2020), 8, Seite 658-666
ISSN Quelle:1423-0356
Abstract:Numerous studies have reported positive effects of exercise training in patients with interstitial lung disease (ILD) on physical capacity and quality of life. However, evidence is rare on the effects of specific forms of training and further pathophysiological mechanisms in these patients. <b><i>Objectives:</i></b> In this multicenter study we aimed to explore the clinical effects of whole-body vibration training (WBVT) in patients with ILD on various outcome measures, including proinflammatory cytokines and myostatin. <b><i>Methods:</i></b> We randomly assigned 26 patients with different forms of multidisciplinary confirmed fibrotic ILDs either to the WBVT group (<i>n</i> = 11; 55% male, 61 ± 14 years old, forced vital capacity 83.2 ± 29.3% predicted, 6-min walking distance [6MWD] 478 ± 79 m) performing 3 months of a standardized training (3 times per week), or to a control training group (CTG, <i>n</i> = 15; 60% male, 63 ± 9 years old, FVC 74.6 ± 20.5% predicted, 6MWD 455 ± 85 m) performing sham WBV training. Training in the two groups was performed on a Galileo<sup>TM</sup> vibration plate (6-20 vs. 5 Hz). The functional assessments before and after the intervention period included pulmonary function, 6MWD test, chair rise test, ultrasonographic measurement of quadriceps muscle thickness (cross-sectional area), quality of life questionnaires, and serum samples. <b><i>Results:</i></b> We observed a significant increase in 6MWD (∆<sub>Training</sub> = 30 m [12-67], <i>p</i> = 0.024) and a decrease of myostatin (∆<sub>Training</sub> = -465 pg/mL [-713 to -166], <i>p</i> = 0.008) in the WBVT group. In contrast, no significant differences were observed in the CTG. <b><i>Conclusions:</i></b> The present study demonstrates that WBVT is able to significantly increase 6MWD and decrease myostatin in patients with fibrotic ILDs. Therefore, WBVT seems to be a beneficial and feasible training modality in ILD patients. <b><i>Clinical Trial Registry:</i></b> German Clinical Trials Registry (DRKS00012930).
DOI:doi:10.1159/000508977
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1159/000508977
 Volltext: https://www.karger.com/Article/FullText/508977
 DOI: https://doi.org/10.1159/000508977
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1736086324
Verknüpfungen:→ Zeitschrift

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