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Verfasst von:Held, Thomas [VerfasserIn]   i
 Uzun-Lang, Kristin [VerfasserIn]   i
 Regnery, Sebastian [VerfasserIn]   i
 Weusthof, Katharina [VerfasserIn]   i
 Hommertgen, Adriane [VerfasserIn]   i
 Jäkel, Cornelia [VerfasserIn]   i
 Tonndorf-Martini, Eric [VerfasserIn]   i
 Krisam, Johannes [VerfasserIn]   i
 Plinkert, Peter K. [VerfasserIn]   i
 Plath, Karim [VerfasserIn]   i
 Freudlsperger, Christian [VerfasserIn]   i
 Moratin, Julius [VerfasserIn]   i
 Krauß, Jürgen [VerfasserIn]   i
 Harrabi, Semi B. [VerfasserIn]   i
 Herfarth, Klaus [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Adeberg, Sebastian [VerfasserIn]   i
Titel:Carbon ion reirradiation compared to intensity-modulated re-radiotherapy for recurrent head and neck cancer (CARE)
Titelzusatz:a randomized controlled trial
Verf.angabe:Thomas Held, Kristin Lang, Sebastian Regnery, Katharina Weusthof, Adriane Hommertgen, Cornelia Jäkel, Eric Tonndorf-Martini, Johannes Krisam, Peter Plinkert, Karim Zaoui, Christian Freudlsperger, Julius Moratin, Jürgen Krauss, Semi B. Harrabi, Klaus Herfarth, Jürgen Debus and Sebastian Adeberg
E-Jahr:2020
Jahr:05 August 2020
Umfang:8 S.
Fussnoten:Gesehen am 22.10.2020
Titel Quelle:Enthalten in: Radiation oncology
Ort Quelle:London : BioMed Central, 2006
Jahr Quelle:2020
Band/Heft Quelle:15(2020) Artikel-Nummer 190, 8 Seiten
ISSN Quelle:1748-717X
Abstract:Background: Intensity-modulated re-radiotherapy (reIMRT) has been established as a standard local treatment option in patients with non-resectable, recurrent head and neck cancer (rHNC). However, the clinical outcome is unfavorable and severe toxicities (≥grade III) occurred in 30-40% of patients. The primary aim of the current trial is to investigate carbon ion reirradiation (reCIRT) compared to reIMRT in patients with rHNC regarding safety/toxicity as well as local control, overall survival (OS), and quality of life (QoL). Methods: The present trial will be performed as a single center, two-armed, prospective phase II study. A maximum of 72 patients will be treated with either reIMRT or reCIRT to evaluate severe (≥grade III) treatment-related toxicities (randomization ratio 1:1). The primary target value is to generate less than 35% acute/subacute severe toxicity (≥grade III), according to the Common Terminology Criteria for Adverse Events v5.0, within 6 months after study treatment. The total dose of reirradiation will range between 51 and 60 Gy or Gy (RBE), depending primarily on the radiotherapy interval and the cumulative dose to organs at risk. Individual dose prescription will be at the discretion of the treating radiation oncologist. The local and distant progression-free survival 12 months after reirradiation, the OS, and the QoL are the secondary endpoints of the trial. Explorative trial objectives are the longitudinal investigation of clinical patient-related parameters, tumor parameters on radiological imaging, and blood-based tumor analytics. Discussion: Recent retrospective studies suggested that reCIRT could represent a feasible and effective treatment modality for rHNC. This current randomized prospective trial is the first to investigate the toxicity and clinical outcome of reCIRT compared to reIMRT in patients with rHNC.
DOI:doi:10.1186/s13014-020-01625-0
URL:kostenfrei: Volltext: https://doi.org/10.1186/s13014-020-01625-0
 DOI: https://doi.org/10.1186/s13014-020-01625-0
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:173620789X
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