| Online-Ressource |
Verfasst von: | Konietzke, Philip [VerfasserIn]  |
| Weinheimer, Oliver [VerfasserIn]  |
| Wagner, Willi Linus [VerfasserIn]  |
| Wünnemann, Felix [VerfasserIn]  |
| Hintze, Christian [VerfasserIn]  |
| Biederer, Jürgen [VerfasserIn]  |
| Heußel, Claus Peter [VerfasserIn]  |
| Kauczor, Hans-Ulrich [VerfasserIn]  |
| Wielpütz, Mark Oliver [VerfasserIn]  |
Titel: | Optimizing airway wall segmentation and quantification by reducing the influence of adjacent vessels and intravascular contrast material with a modified integral-based algorithm in quantitative computed tomography |
Verf.angabe: | Philip Konietzke, Oliver Weinheimer, Willi L. Wagner, Felix Wuennemann, Christian Hintze, Juergen Biederer, Claus P. Heussel, Hans-Ulrich Kauczor, Mark O. Wielpütz |
E-Jahr: | 2020 |
Jahr: | August 19, 2020 |
Umfang: | 14 S. |
Fussnoten: | Gesehen am 22.10.2020 |
Titel Quelle: | Enthalten in: PLOS ONE |
Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 15(2020,8) Artikel-Nummer e0237939, 14 Seiten |
ISSN Quelle: | 1932-6203 |
Abstract: | Introduction Quantitative analysis of multi-detector computed tomography (MDCT) plays an increasingly important role in assessing airway disease. Depending on the algorithms used, airway dimensions may be over- or underestimated, primarily if contrast material was used. Therefore, we tested a modified integral-based method (IBM) to address this problem. Methods Temporally resolved cine-MDCT was performed in seven ventilated pigs in breath-hold during iodinated contrast material (CM) infusion over 60s. Identical slices in non-enhanced (NE), pulmonary-arterial (PA), systemic-arterial (SA), and venous phase (VE) were subjected to an in-house software using a standard and a modified IBM. Total diameter (TD), lumen area (LA), wall area (WA), and wall thickness (WT) were measured for ten extra- and six intrapulmonary airways. Results The modified IBM significantly reduced TD by 7.6%, LA by 12.7%, WA by 9.7%, and WT by 3.9% compared to standard IBM on non-enhanced CT (p<0.05). Using standard IBM, CM led to a decrease of all airway parameters compared to NE. For example, LA decreased from 80.85±49.26mm2 at NE, to 75.14±47.96mm2 (-7.1%) at PA (p<0.001), 74.96±48.55mm2 (-7.3%) at SA (p<0.001), and to 78.95±48.94mm2 (-2.4%) at VE (p = 0.200). Using modified IBM, the differences were reduced to -3.1% at PA, -2.9% at SA and -0.7% at VE (p<0.001; p<0.001; p = 1.000). Conclusions The modified IBM can optimize airway wall segmentation and reduce the influence of CM on quantitative CT. This allows a more precise measurement as well as potentially the comparison of enhanced with non-enhanced scans in inflammatory airway disease. |
DOI: | doi:10.1371/journal.pone.0237939 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0237939 |
| Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237939 |
| DOI: https://doi.org/10.1371/journal.pone.0237939 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Algorithms |
| Aorta |
| Bronchi |
| Computed axial tomography |
| Computer software |
| Inferior vena cava |
| Pulmonary arteries |
| Recombinase polymerase amplification |
K10plus-PPN: | 173622655X |
Verknüpfungen: | → Zeitschrift |
Optimizing airway wall segmentation and quantification by reducing the influence of adjacent vessels and intravascular contrast material with a modified integral-based algorithm in quantitative computed tomography / Konietzke, Philip [VerfasserIn]; August 19, 2020 (Online-Ressource)