Selenium deficiency is associated with mortality risk from COVID-19

• Verfasst von: Moghaddam-Alvandi, Arash [VerfasserIn]
• Verfasst von: Heller, Raban [VerfasserIn]
• Verfasst von: Sun, Qian [VerfasserIn]
• Verfasst von: Seelig, Julian [VerfasserIn]
• Verfasst von: Cherkezov, Asan [VerfasserIn]
• Verfasst von: Seibert, Linda [VerfasserIn]
• Verfasst von: Hackler, Julian [VerfasserIn]
• Verfasst von: Seemann, Petra [VerfasserIn]
• Verfasst von: Diegmann, Joachim [VerfasserIn]
• Verfasst von: Pilz, Maximilian [VerfasserIn]
• Verfasst von: Bachmann, Manuel [VerfasserIn]
• Verfasst von: Minich, Waldemar B. [VerfasserIn]
• Verfasst von: Schomburg, Lutz [VerfasserIn]
• Titel: Selenium deficiency is associated with mortality risk from COVID-19
• Verf.angabe: Arash Moghaddam, Raban Arved Heller, Qian Sun, Julian Seelig, Asan Cherkezov, Linda Seibert, Julian Hackler, Petra Seemann, Joachim Diegmann, Maximilian Pilz, Manuel Bachmann, Waldemar B. Minich and Lutz Schomburg
• E-Jahr: 2020
• Jahr: 16 July 2020
• Umfang: 13 S.
• Fussnoten: Gesehen am 22.10.2020
• Titel Quelle: Enthalten in: Nutrients
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2020
• Band/Heft Quelle: 12(2020,7) Artikel-Nummer 2098, 13 Seiten
• ISSN Quelle: 2072-6643
• DOI: doi:10.3390/nu12072098
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: COVID-19
• Sach-SW: inflammation
• Sach-SW: micronutrient
• Sach-SW: selenoprotein P
• Sach-SW: trace element
• K10plus-PPN: 1736267191

Abstract

SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-balanced immune response. The mortality risk from a severe disease like sepsis or polytrauma is inversely related to Se status. We hypothesized that this relation also applies to COVID-19. Serum samples (n = 166) from COVID-19 patients (n = 33) were collected consecutively and analyzed for total Se by X-ray fluorescence and selenoprotein P (SELENOP) by a validated ELISA. Both biomarkers showed the expected strong correlation (r = 0.7758, p < 0.001), pointing to an insufficient Se availability for optimal selenoprotein expression. In comparison with reference data from a European cross-sectional analysis (EPIC, n = 1915), the patients showed a pronounced deficit in total serum Se (mean &plusmn; SD, 50.8 &plusmn; 15.7 vs. 84.4 &plusmn; 23.4 &micro;g/L) and SELENOP (3.0 &plusmn; 1.4 vs. 4.3 &plusmn; 1.0 mg/L) concentrations. A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 &micro;g/L and [SELENOP] < 2.56 mg/L, was present in 43.4% and 39.2% of COVID samples, respectively. The Se status was significantly higher in samples from surviving COVID patients as compared with non-survivors (Se; 53.3 &plusmn; 16.2 vs. 40.8 &plusmn; 8.1 &micro;g/L, SELENOP; 3.3 &plusmn; 1.3 vs. 2.1 &plusmn; 0.9 mg/L), recovering with time in survivors while remaining low or even declining in non-survivors. We conclude that Se status analysis in COVID patients provides diagnostic information. However, causality remains unknown due to the observational nature of this study. Nevertheless, the findings strengthen the notion of a relevant role of Se for COVID convalescence and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients.