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Status: Bibliographieeintrag

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Verfasst von:Palm, Frederick [VerfasserIn]   i
 Pussinen, Pirkko J. [VerfasserIn]   i
 Aigner, Annette [VerfasserIn]   i
 Becher, Heiko [VerfasserIn]   i
 Buggle, Florian [VerfasserIn]   i
 Bauer, Matthias F. [VerfasserIn]   i
 Grond-Ginsbach, Caspar [VerfasserIn]   i
 Safer, Anton [VerfasserIn]   i
 Urbanek, Christian [VerfasserIn]   i
 Grau, Armin J. [VerfasserIn]   i
Titel:Association between infectious burden, socioeconomic status, and ischemic stroke
Verf.angabe:Frederick Palm, Pirkko J. Pussinen, Annette Aigner, Heiko Becher, Florian Buggle, Matthias F. Bauer, Caspar Grond-Ginsbach, Anton Safer, Christian Urbanek, Armin J. Grau
E-Jahr:2016
Jahr:5 October 2016
Umfang:7 S.
Fussnoten:Gesehen am 23.10.2020
Titel Quelle:Enthalten in: Atherosclerosis
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1970
Jahr Quelle:2016
Band/Heft Quelle:254(2016), Seite 117-123
ISSN Quelle:1879-1484
Abstract:Background and aims - Infectious diseases contribute to stroke risk, and are associated with socioeconomic status (SES). We tested the hypotheses that the aggregate burden of infections increases the risk of ischemic stroke (IS) and partly explains the association between low SES and ischemic stroke. - Methods - In a case-control study with 470 ischemic stroke patients and 809 age- and sex-matched controls, randomly selected from the population, antibodies against the periodontal microbial agents Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, against Chlamydia pneumonia, Mycoplasma pneumoniae (IgA and IgG), and CagA-positive Helicobacter pylori (IgG) were assessed. - Results - IgA seropositivity to two microbial agents was significantly associated with IS after adjustment for SES (OR 1.45 95% CI 1.01-2.08), but not in the fully adjusted model (OR 1.32 95% CI 0.86-2.02). By trend, cumulative IgA seropositivity was associated with stroke due to large vessel disease (LVD) after full adjustment (OR 1.88, 95% CI 0.96-3.69). Disadvantageous childhood SES was associated with higher cumulative seropositivity in univariable analyses, however, its strong impact on stroke risk was not influenced by seroepidemiological data in the multivariable model. The strong association between adulthood SES and stroke was rendered nonsignificant when factors of dental care were adjusted for. - Conclusions - Infectious burden assessed with five microbial agents did not independently contribute to ischemic stroke consistently, but may contribute to stroke due to LVD. High infectious burden may not explain the association between childhood SES and stroke risk. Lifestyle factors that include dental negligence may contribute to the association between disadvantageous adulthood SES and stroke.
DOI:doi:10.1016/j.atherosclerosis.2016.10.008
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.atherosclerosis.2016.10.008
 Volltext: http://www.sciencedirect.com/science/article/pii/S0021915016314113
 DOI: https://doi.org/10.1016/j.atherosclerosis.2016.10.008
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Infection
 Ischemic stroke
 Large vessel disease
 Periodontitis
 Socioeconomic status
K10plus-PPN:173648642X
Verknüpfungen:→ Zeitschrift

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