Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Armstrong, Paul W. [VerfasserIn]   i
 Westerhout, Cynthia M. [VerfasserIn]   i
 Fu, Yuling [VerfasserIn]   i
 Harrington, Robert A. [VerfasserIn]   i
 Storey, Robert F. [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
 James, Stefan [VerfasserIn]   i
 Wallentin, Lars [VerfasserIn]   i
Titel:Quantitative ST-depression in acute coronary syndromes
Titelzusatz:the PLATO electrocardiographic substudy
Verf.angabe:Paul W. Armstrong, MD, Cynthia M. Westerhout, PhD, Yuling Fu, MD, Robert A. Harrington, MD, Robert F. Storey, MD, DM, Hugo Katus, MD, Stefan James, MD, PhD, Lars Wallentin, MD, PhD
E-Jahr:2013
Jahr:21 June 2013
Umfang:8 S.
Fussnoten:Gesehen am 26.10.2020
Titel Quelle:Enthalten in: The American journal of medicine
Ort Quelle:New York, NY : Excerpta Medica, 1946
Jahr Quelle:2013
Band/Heft Quelle:126(2013), 8, Seite 723-729, 729.e1
ISSN Quelle:1555-7162
Abstract:Background - We evaluated whether electrocardiogram (ECG) characteristics were aligned with clinical outcomes and the effect of ticagrelor within the diverse spectrum of non-ST-elevation acute coronary syndrome patients enrolled in the PLATelet inhibition and patient Outcomes (PLATO) trial. - Methods - There were 8884 PLATO patients who had baseline ECGs assessed by a core laboratory; of these, 4935 had an ECG at hospital discharge that also was assessed. Associations with study treatment on vascular death or myocardial infarction within 1 year were examined. - Results - At baseline, most patients had either no or ≤0.5 mm of ST-segment depression (57%); 26% had 1.0 mm, and 17% had more extensive depression (>1.0 mm). Across the baseline ST-segment depression strata, there was a consistent treatment benefit with ticagrelor versus clopidogrel on vascular death/myocardial infarction. The extent of residual ST-segment depression at discharge was similar in the treatment groups, and the treatment effect did not differ by the extent of discharge ST-segment depression. There was a progressive increase in vascular death/myocardial infarction with increasing extent of baseline ST-segment depression (1.0 mm [vs no/0.5 mm]: hazard ratio [HR] 1.22; 95% confidence interval [CI], 1.03-1.45; >1.0 mm: HR 1.49; 95% CI, 1.24-1.78; P <.001) and at discharge (HR 1.28; 95% CI, 1.02-1.61; HR 2.13; 95% CI, 1.54-2.95; P <.001). - Conclusion - The treatment effect of ticagrelor among non-ST-segment-elevation acute coronary syndrome patients was consistently expressed across all baseline ST-segment depression strata. There was no indication of an anti-ischemic benefit of ticagrelor as reflected on the discharge ECG. Our data affirm the independent prognostic relationship of both baseline and hospital discharge ST-segment depression on outcomes within 1 year in non-ST-segment-elevation acute coronary syndrome patients.
DOI:doi:10.1016/j.amjmed.2013.01.038
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.amjmed.2013.01.038
 Volltext: http://www.sciencedirect.com/science/article/pii/S0002934313003951
 DOI: https://doi.org/10.1016/j.amjmed.2013.01.038
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Acute coronary syndrome
 Electrocardiography
 Platelet inhibition
K10plus-PPN:1736590693
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68653929   QR-Code
zum Seitenanfang