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Status: Bibliographieeintrag

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Verfasst von:Arns, Wolfgang [VerfasserIn]   i
 Sommerer, Claudia [VerfasserIn]   i
 Glander, Petra [VerfasserIn]   i
 Ariatabar, Toofan [VerfasserIn]   i
 Porstner, Martina [VerfasserIn]   i
 May, Christoph [VerfasserIn]   i
 Paulus, Eva-Maria [VerfasserIn]   i
 Shipkova, Maria [VerfasserIn]   i
 Fischer, Wolfgang [VerfasserIn]   i
 Liefeldt, Lutz [VerfasserIn]   i
 Hackenberg, Ruth [VerfasserIn]   i
 Schemmer, Peter [VerfasserIn]   i
 Domhan, Sophie [VerfasserIn]   i
 Zeier, Martin [VerfasserIn]   i
 Budde, Klemens [VerfasserIn]   i
Titel:A randomized trial of intensified vs. standard dosing for enteric-coated mycophenolate sodium in de novo kidney transplant recipients
Titelzusatz:results at 1 year
Verf.angabe:Wolfgang Arns, Claudia Sommerer, Petra Glander, Toofan Ariatabar, Martina Porstner, Christoph May, Eva-Maria Paulus, Maria Shipkova, Wolfgang Fischer, Lutz Liefeldt, Ruth Hackenberg, Peter Schemmer, Sophie Domhan, Martin Zeier, Klemens Budde
Jahr:2013
Umfang:11 S.
Fussnoten:Gesehen am 26.10.2020
Titel Quelle:Enthalten in: Clinical nephrology
Ort Quelle:Deisenhofen, Munich : Dustri-Verl. Feistle, 2002
Jahr Quelle:2013
Band/Heft Quelle:79(2013), 6, Seite 421-431
Abstract:In a 6-month prospective, openlabel, multicenter study, 128 de novo kidney transplant patients receiving cyclosporine (CsA) and steroids were randomized to an intensified regimen of enteric-coated mycophenolate sodium (EC-MPS) or to a standard EC-MPS regimen to Week 6 posttransplant, after which the regimen was identical. In a follow-up study to Month 12 post-transplant (49 intensified regimen, 52 standard regimen), the reduced rate of BPAR observed at Month 6 (intensified regimen 3.2%, standard regimen 16.9%, p = 0.016) was maintained at Month 12 (4.8% vs. 18.5%, p = 0.026). Estimated GFR (Cockcroft-Gault) at Month 12 was comparable in the intensified group (mean (SD) 54.8 (22.9) ml/min) vs. the standard group (mean (SD) 57.5 (23.6) ml/min, p = 0.83). The incidence of adverse events and serious adverse events at Month 12 was similar in both treatment groups, although adverse events with a suspected relation to study drug were reported in 69.8% and 50.8% of patients in the intensified and standard regimen groups, respectively (p = 0.032). Infections and hematological parameters were similar between groups. In conclusion, an early regimen of intensified EC-MPS with CsA and steroids achieves a low rate of BPAR over the first year after kidney transplantation with similar renal function to a standard regimen, and without a clinically relevant impact on safety.
DOI:doi:10.5414/CN107908
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.5414/CN107908
 DOI: https://doi.org/10.5414/CN107908
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adult
 Aged
 Cyclosporine
 Female
 Follow-Up Studies
 Germany
 Glomerular Filtration Rate
 Glucocorticoids
 Graft Rejection
 Graft Survival
 Humans
 Immunosuppressive Agents
 Kidney Transplantation
 Male
 Middle Aged
 Mycophenolic Acid
 Prospective Studies
 Tablets, Enteric-Coated
 Treatment Outcome
K10plus-PPN:1736601237
Verknüpfungen:→ Zeitschrift

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