| Online-Ressource |
Verfasst von: | Arns, Wolfgang [VerfasserIn]  |
| Sommerer, Claudia [VerfasserIn]  |
| Glander, Petra [VerfasserIn]  |
| Ariatabar, Toofan [VerfasserIn]  |
| Porstner, Martina [VerfasserIn]  |
| May, Christoph [VerfasserIn]  |
| Paulus, Eva-Maria [VerfasserIn]  |
| Shipkova, Maria [VerfasserIn]  |
| Fischer, Wolfgang [VerfasserIn]  |
| Liefeldt, Lutz [VerfasserIn]  |
| Hackenberg, Ruth [VerfasserIn]  |
| Schemmer, Peter [VerfasserIn]  |
| Domhan, Sophie [VerfasserIn]  |
| Zeier, Martin [VerfasserIn]  |
| Budde, Klemens [VerfasserIn]  |
Titel: | A randomized trial of intensified vs. standard dosing for enteric-coated mycophenolate sodium in de novo kidney transplant recipients |
Titelzusatz: | results at 1 year |
Verf.angabe: | Wolfgang Arns, Claudia Sommerer, Petra Glander, Toofan Ariatabar, Martina Porstner, Christoph May, Eva-Maria Paulus, Maria Shipkova, Wolfgang Fischer, Lutz Liefeldt, Ruth Hackenberg, Peter Schemmer, Sophie Domhan, Martin Zeier, Klemens Budde |
Jahr: | 2013 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 26.10.2020 |
Titel Quelle: | Enthalten in: Clinical nephrology |
Ort Quelle: | Deisenhofen, Munich : Dustri-Verl. Feistle, 2002 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 79(2013), 6, Seite 421-431 |
Abstract: | In a 6-month prospective, openlabel, multicenter study, 128 de novo kidney transplant patients receiving cyclosporine (CsA) and steroids were randomized to an intensified regimen of enteric-coated mycophenolate sodium (EC-MPS) or to a standard EC-MPS regimen to Week 6 posttransplant, after which the regimen was identical. In a follow-up study to Month 12 post-transplant (49 intensified regimen, 52 standard regimen), the reduced rate of BPAR observed at Month 6 (intensified regimen 3.2%, standard regimen 16.9%, p = 0.016) was maintained at Month 12 (4.8% vs. 18.5%, p = 0.026). Estimated GFR (Cockcroft-Gault) at Month 12 was comparable in the intensified group (mean (SD) 54.8 (22.9) ml/min) vs. the standard group (mean (SD) 57.5 (23.6) ml/min, p = 0.83). The incidence of adverse events and serious adverse events at Month 12 was similar in both treatment groups, although adverse events with a suspected relation to study drug were reported in 69.8% and 50.8% of patients in the intensified and standard regimen groups, respectively (p = 0.032). Infections and hematological parameters were similar between groups. In conclusion, an early regimen of intensified EC-MPS with CsA and steroids achieves a low rate of BPAR over the first year after kidney transplantation with similar renal function to a standard regimen, and without a clinically relevant impact on safety. |
DOI: | doi:10.5414/CN107908 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.5414/CN107908 |
| DOI: https://doi.org/10.5414/CN107908 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Adult |
| Aged |
| Cyclosporine |
| Female |
| Follow-Up Studies |
| Germany |
| Glomerular Filtration Rate |
| Glucocorticoids |
| Graft Rejection |
| Graft Survival |
| Humans |
| Immunosuppressive Agents |
| Kidney Transplantation |
| Male |
| Middle Aged |
| Mycophenolic Acid |
| Prospective Studies |
| Tablets, Enteric-Coated |
| Treatment Outcome |
K10plus-PPN: | 1736601237 |
Verknüpfungen: | → Zeitschrift |
¬A¬ randomized trial of intensified vs. standard dosing for enteric-coated mycophenolate sodium in de novo kidney transplant recipients / Arns, Wolfgang [VerfasserIn]; 2013 (Online-Ressource)