| |  Online-Ressource |
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| Verfasst von: | Hu, Hai-Yu [VerfasserIn]  |
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| | Gehrig, Stefanie [VerfasserIn] |
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| | Reither, Gregor [VerfasserIn] |
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| | Subramanian, Devaraj [VerfasserIn] |
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| | Mall, Marcus A. [VerfasserIn] |
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| | Plettenburg, Oliver [VerfasserIn] |
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| | Schultz, Carsten [VerfasserIn] |
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| Titel: | FRET-based and other fluorescent proteinase probes |
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| Verf.angabe: | Hai-Yu Hu, Stefanie Gehrig, Gregor Reither, Devaraj Subramanian, Marcus A. Mall, Oliver Plettenburg and Carsten Schultz |
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| E-Jahr: | 2014 |
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| Jahr: | 27 January 2014 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 27.10.2020 |
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| Titel Quelle: | Enthalten in: Biotechnology journal |
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| Ort Quelle: | Weinheim : Wiley-VCH, 2006 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 9(2014), 2, Seite 266-281 |
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| ISSN Quelle: | 1860-7314 |
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| Abstract: | The continuous detection of enzyme activities and their application in medical diagnostics is one of the challenges in the translational sciences. Proteinases represent one of the largest groups of enzymes in the human genome and many diseases are based on malfunctions of proteolytic activity. Fluorescent sensors may shed light on regular and irregular proteinase activity in vitro and in vivo and provide a deeper insight into the function of these enzymes and their role in pathophysiological processes. The focus of this review is on Förster resonance energy transfer (FRET)-based proteinase sensors and reporters because these probes are most likely to provide quantitative data. The medical relevance of proteinases are discussed using lung diseases as a prominent example. Probe design and probe targeting are described and fluorescent probe development for disease-relevant proteinases, including matrix-metalloproteinases, cathepsins, caspases, and other selected proteinases, is reviewed. |
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| DOI: | doi:10.1002/biot.201300201 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/biot.201300201 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/biot.201300201 |
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| | DOI: https://doi.org/10.1002/biot.201300201 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Activity-based probes |
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| | Cathepsins |
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| | Cell targeting |
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| | Chronic inflammatory lung disease |
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| | Matrix metalloproteinases |
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| K10plus-PPN: | 173664484X |
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| Verknüpfungen: | → Zeitschrift |
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FRET-based and other fluorescent proteinase probes / Hu, Hai-Yu [VerfasserIn]; 27 January 2014 (Online-Ressource)
