mRNA 3′end processing

• Verfasst von: Hollerer, Ina [VerfasserIn]
• Verfasst von: Grund, Kerstin [VerfasserIn]
• Verfasst von: Hentze, Matthias W. [VerfasserIn]
• Verfasst von: Kulozik, Andreas [VerfasserIn]
• Titel: mRNA 3′end processing
• Titelzusatz: a tale of the tail reaches the clinic
• Verf.angabe: Ina Hollerer, Kerstin Grund, Matthias W. Hentze & Andreas E Kulozik
• Jahr: 2014
• Umfang: 11 S.
• Teil: volume:6
• Teil: year:2014
• Teil: number:1
• Teil: pages:16-26
• Teil: extent:11
• Fussnoten: Published online 9 October 2013 ; Gesehen am 27.10.2020
• Titel Quelle: Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine
• Ort Quelle: Weinheim : Wiley-VCH, 2009
• Jahr Quelle: 2014
• Band/Heft Quelle: 6(2014), 1, Seite 16-26
• ISSN Quelle: 1757-4684
• DOI: doi:10.1002/emmm.201303300
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: clinical importance of 3′ end mRNA processing
• Sach-SW: control of polyadenylation
• Sach-SW: post-transcriptional gene regulation
• Sach-SW: regulation of 3′ end mRNA processing
• K10plus-PPN: 1736690531

Abstract

Abstract Recent advances reveal mRNA 3?end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3?end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3?end processing plays a central role in fundamental physiology such as blood coagulation and innate immunity. In addition, errors in mRNA 3?end processing have been associated with a broad spectrum of human diseases, including cancer. We summarize and discuss the paradigmatic shift in the understanding of 3?end processing as a mechanism of posttranscriptional gene regulation that has reached clinical medicine.