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Verfasst von:Astani, Akram [VerfasserIn]   i
 Zimmermann, Stefan [VerfasserIn]   i
 Hassan, Ebrahim [VerfasserIn]   i
 Reichling, Jürgen [VerfasserIn]   i
 Sensch, K. H. [VerfasserIn]   i
 Schnitzler, Paul [VerfasserIn]   i
Titel:Antimicrobial activity of propolis special extract GH 2002 against multidrug-resistant clinical isolates
Verf.angabe:A. Astani, S. Zimmermann, E. Hassan, J. Reichling, K.H. Sensch, P. Schnitzler
Jahr:2013
Umfang:7 S.
Fussnoten:Gesehen am 27.10.2020
Titel Quelle:Enthalten in: Die Pharmazie <Eschborn>
Ort Quelle:Eschborn : Avoxa, Mediengruppe Deutscher Apotheker, 1995
Jahr Quelle:2013
Band/Heft Quelle:68(2013), 8, Seite 695-701
Abstract:The need to discover and develop alternative therapies to treat multidrug-resistant bacterial infections is timely. The aim of this study was to examine the antimicrobial potential of propolis, as a purified and concentrated special extract GH 2002, against clinical isolates of Streptococcus pyogenes, methicillin-resistent Stapylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE) and Candida. Minimal inhibitory concentrations (MICs) and minimal microbicidial concentrations (MMCs) of propolis against microbial pathogens were evaluated using the broth microdilution method. Propolis extract GH 2002 revealed low MICs in the range of 0.03 to 2 mg/ml against S. pyogenes, S. aureus, E. faecium and Candida. A high bactericidal activity of propolis extract in the range of 0.06 to 1.0 mg/ml was determined for S. pyogenes and S. aureus, however propolis was not bactericidal against E. faecium. Propolis concentrations between 0.6 and 2.4 mg/ml displayed fungicidal activity against different Candida species. Whereas all tested MRSA strains were highly susceptible against propolis, only minor activity was found against VRE strains. Time-kill curves demonstrated a high antimicrobial activity at low MICs already after few hours of incubation against reference strains, clinical antibiotic-susceptible strains, clinical antifungal susceptible strains as well as all tested clinical MRSA strains, but not against VRE strains. In conclusion, clinical drug-sensitive as well as some clinical multidrug-resistant microbial isolates, i.e. MRSA, were susceptible to propolis with different degrees of susceptibility. These results suggest that the special propolis extract GH2002 might be used in the development of alternative products for therapy of microbial infections.
DOI:doi:10.1691/ph.2013.2907
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag ; Resolving-System: https://doi.org/10.1691/ph.2013.2907
 Volltext: https://www.ingentaconnect.com/content/govi/pharmaz/2013/00000068/00000008/art00010?crawler=true
 DOI: https://doi.org/10.1691/ph.2013.2907
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Anti-Infective Agents
 Candida
 Drug Resistance, Fungal
 Drug Resistance, Multiple, Bacterial
 Enterococcus faecium
 Methicillin-Resistant Staphylococcus aureus
 Microbial Sensitivity Tests
 Propolis
 Streptococcus pyogenes
 Vancomycin Resistance
K10plus-PPN:1736692461
Verknüpfungen:→ Zeitschrift

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