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| Verfasst von: | Andrade, Carolina [VerfasserIn]  |
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| | Fleckenstein, Hannah [VerfasserIn] |
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| | Thomson-Luque, Richard [VerfasserIn] |
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| | Doumbo, Safiatou [VerfasserIn] |
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| | Ferreira Lima, Náthalia [VerfasserIn] |
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| | Anderson, Carrie L. [VerfasserIn] |
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| | Hibbert, Julia [VerfasserIn] |
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| | Hopp, Christine S. [VerfasserIn] |
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| | Tran, Tuan M. [VerfasserIn] |
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| | Li, Shanping [VerfasserIn] |
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| | Niangaly, Moussa [VerfasserIn] |
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| | Cisse, Hamidou [VerfasserIn] |
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| | Doumtabe, Didier [VerfasserIn] |
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| | Skinner, Jeff [VerfasserIn] |
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| | Sturdevant, Dan [VerfasserIn] |
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| | Ricklefs, Stacy [VerfasserIn] |
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| | Virtaneva, Kimmo [VerfasserIn] |
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| | Asghar, Muhammad [VerfasserIn] |
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| | Homann, Manijeh Vafa [VerfasserIn] |
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| | Turner, Louise [VerfasserIn] |
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| | Martins, Joana [VerfasserIn] |
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| | Allman, Erik L. [VerfasserIn] |
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| | N’Dri, Marie-Esther [VerfasserIn] |
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| | Winkler, Volker [VerfasserIn] |
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| | Llinás, Manuel [VerfasserIn] |
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| | Lavazec, Catherine [VerfasserIn] |
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| | Martens, Craig [VerfasserIn] |
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| | Färnert, Anna [VerfasserIn] |
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| | Kayentao, Kassoum [VerfasserIn] |
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| | Ongoiba, Aissata [VerfasserIn] |
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| | Lavstsen, Thomas [VerfasserIn] |
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| | Osório, Nuno S. [VerfasserIn] |
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| | Otto, Thomas D. [VerfasserIn] |
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| | Recker, Mario [VerfasserIn] |
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| | Traore, Boubacar [VerfasserIn] |
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| | Crompton, Peter D. [VerfasserIn] |
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| | Portugal, Silvia [VerfasserIn] |
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| Titel: | Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season |
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| Verf.angabe: | Carolina M. Andrade, Hannah Fleckenstein, Richard Thomson-Luque, Safiatou Doumbo, Nathalia F. Lima, Carrie Anderson, Julia Hibbert, Christine S. Hopp, Tuan M. Tran, Shanping Li, Moussa Niangaly, Hamidou Cisse, Didier Doumtabe, Jeff Skinner, Dan Sturdevant, Stacy Ricklefs, Kimmo Virtaneva, Muhammad Asghar, Manijeh Vafa Homann, Louise Turner, Joana Martins, Erik L. Allman, Marie-Esther N’Dri, Volker Winkler, Manuel Llinás, Catherine Lavazec, Craig Martens, Anna Färnert, Kassoum Kayentao, Aissata Ongoiba, Thomas Lavstsen, Nuno S. Osório, Thomas D. Otto, Mario Recker, Boubacar Traore, Peter D. Crompton and Silvia Portugal |
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| E-Jahr: | 2020 |
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| Jahr: | 26 October 2020 |
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| Umfang: | 12 S. |
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| Teil: | volume:26 |
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| | year:2020 |
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| | pages:1929-1940 |
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| | extent:12 |
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| Fussnoten: | Das PDF enthält einen Anhang von 17 Seiten ; Gesehen am 28.10.2020 |
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| Titel Quelle: | Enthalten in: Nature medicine |
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| Ort Quelle: | New York, NY : Nature America Inc., 1995 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 26(2020), Seite 1929-1940 |
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| ISSN Quelle: | 1546-170X |
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| Abstract: | The dry season is a major challenge for Plasmodium falciparum parasites in many malaria endemic regions, where water availability limits mosquito vectors to only part of the year. How P. falciparum bridges two transmission seasons months apart, without being cleared by the human host or compromising host survival, is poorly understood. Here we show that low levels of P. falciparum parasites persist in the blood of asymptomatic Malian individuals during the 5- to 6-month dry season, rarely causing symptoms and minimally affecting the host immune response. Parasites isolated during the dry season are transcriptionally distinct from those of individuals with febrile malaria in the transmission season, coinciding with longer circulation within each replicative cycle of parasitized erythrocytes without adhering to the vascular endothelium. Low parasite levels during the dry season are not due to impaired replication but rather to increased splenic clearance of longer-circulating infected erythrocytes, which likely maintain parasitemias below clinical and immunological radar. We propose that P. falciparum virulence in areas of seasonal malaria transmission is regulated so that the parasite decreases its endothelial binding capacity, allowing increased splenic clearance and enabling several months of subclinical parasite persistence. |
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| DOI: | doi:10.1038/s41591-020-1084-0 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41591-020-1084-0 |
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| | Volltext: https://www.nature.com/articles/s41591-020-1084-0 |
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| | DOI: https://doi.org/10.1038/s41591-020-1084-0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1736842072 |
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| Verknüpfungen: | → Zeitschrift |
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Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season / Andrade, Carolina [VerfasserIn]; 26 October 2020 (Online-Ressource)
