| |  Online-Ressource |
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| Verfasst von: | Ziak, Jakub [VerfasserIn]  |
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| | Weissova, Romana [VerfasserIn] |
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| | Jeřábková, Kateřina [VerfasserIn] |
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| | Janikova, Martina [VerfasserIn] |
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| | Maimon, Roy [VerfasserIn] |
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| | Petrasek, Tomas [VerfasserIn] |
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| | Pukajova, Barbora [VerfasserIn] |
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| | Kleisnerova, Marie [VerfasserIn] |
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| | Wang, Mengzhe [VerfasserIn] |
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| | Brill, Monika S. [VerfasserIn] |
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| | Kasparek, Petr [VerfasserIn] |
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| | Zhou, Xunlei [VerfasserIn] |
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| | Alvarez-Bolado, Gonzalo [VerfasserIn] |
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| | Sedlacek, Radislav [VerfasserIn] |
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| | Misgeld, Thomas [VerfasserIn] |
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| | Stuchlik, Ales [VerfasserIn] |
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| | Perlson, Eran [VerfasserIn] |
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| | Balastik, Martin [VerfasserIn] |
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| Titel: | CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling |
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| Verf.angabe: | Jakub Ziak, Romana Weissova, Kateřina Jeřábková, Martina Janikova, Roy Maimon, Tomas Petrasek, Barbora Pukajova, Marie Kleisnerova, Mengzhe Wang, Monika S. Brill, Petr Kasparek, Xunlei Zhou, Gonzalo Alvarez-Bolado, Radislav Sedlacek, Thomas Misgeld, Ales Stuchlik, Eran Perlson & Martin Balastik |
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| E-Jahr: | 2020 |
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| Jahr: | 9 January 2020 |
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| Umfang: | 22 S. |
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| Fussnoten: | Gesehen am 28.10.2020 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO reports |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2000 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 21(2020,3) Artikel-Nummer e48512, 22 Seiten |
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| ISSN Quelle: | 1469-3178 |
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| Abstract: | Regulation of axon guidance and pruning of inappropriate synapses by class 3 semaphorins are key to the development of neural circuits. Collapsin response mediator protein 2 (CRMP2) has been shown to regulate axon guidance by mediating semaphorin 3A (Sema3A) signaling; however, nothing is known about its role in synapse pruning. Here, using newly generated crmp2-/- mice we demonstrate that CRMP2 has a moderate effect on Sema3A-dependent axon guidance in vivo, and its deficiency leads to a mild defect in axon guidance in peripheral nerves and the corpus callosum. Surprisingly, crmp2-/- mice display prominent defects in stereotyped axon pruning in hippocampus and visual cortex and altered dendritic spine remodeling, which is consistent with impaired Sema3F signaling and with models of autism spectrum disorder (ASD). We demonstrate that CRMP2 mediates Sema3F signaling in primary neurons and that crmp2-/- mice display ASD-related social behavior changes in the early postnatal period as well as in adults. Together, we demonstrate that CRMP2 mediates Sema3F-dependent synapse pruning and its dysfunction shares histological and behavioral features of ASD. |
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| DOI: | doi:10.15252/embr.201948512 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.15252/embr.201948512 |
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| | Volltext: https://www.embopress.org/doi/full/10.15252/embr.201948512 |
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| | DOI: https://doi.org/10.15252/embr.201948512 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | axon guidance |
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| | collapsin response mediator protein 2 |
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| | dendritic spines |
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| | semaphorins |
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| | synapse pruning |
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| K10plus-PPN: | 1736853228 |
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| Verknüpfungen: | → Zeitschrift |
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CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling / Ziak, Jakub [VerfasserIn]; 9 January 2020 (Online-Ressource)
