| |  Online-Ressource |
|---|
| Verfasst von: | Paller, Amy S. [VerfasserIn]  |
|---|
| | Fölster-Holst, Regina [VerfasserIn] |
|---|
| | Chen, Suephy C. [VerfasserIn] |
|---|
| | Diepgen, Thomas L. [VerfasserIn] |
|---|
| | Elmets, Craig [VerfasserIn] |
|---|
| | Margolis, David J. [VerfasserIn] |
|---|
| | Pollock, Brad H. [VerfasserIn] |
|---|
| Titel: | No evidence of increased cancer incidence in children using topical tacrolimus for atopic dermatitis |
|---|
| Verf.angabe: | Amy S. Paller, MD, Regina Fölster-Holst, MD, Suephy C. Chen, MD, MS, Thomas L. Diepgen, MD, PhD, Craig Elmets, MD, David J. Margolis, MD, PhD, and Brad H. Pollock, MPH, PhD |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 1 April 2020 |
|---|
| Umfang: | 7 S. |
|---|
| Fussnoten: | Gesehen am 30.10.2020 |
|---|
| Titel Quelle: | Enthalten in: American Academy of DermatologyJournal of the American Academy of Dermatology |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1979 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 83(2020), 2, Seite 375-381 |
|---|
| ISSN Quelle: | 1097-6787 |
|---|
| Abstract: | Background - Long-term safety of topical calcineurin inhibitors is not well understood. APPLES (A Prospective Pediatric Longitudinal Evaluation to Assess the Long-Term Safety of Tacrolimus Ointment for the Treatment of Atopic Dermatitis; NCT00475605) examined incidence of lymphoma and other cancers in a pediatric population with atopic dermatitis. - Objective - To quantify incident malignancies during 10 years in children with atopic dermatitis who used topical tacrolimus for ≥6 weeks. - Methods - Standardized incidence ratios for cancer events were analyzed relative to sex-, age-, and race-matched control data from national cancer registries. - Results - There were 7954 eligible patients enrolled at 314 sites in 9 countries. During 44,629 person-years, 6 confirmed incident cancers occurred (standardized incidence ratio, 1.01; 95% confidence interval, 0.37-2.20). No lymphomas occurred. - Limitations - Observational prospective cohort study. - Conclusion - The cancer incidence was as expected, given matched background data. This finding provides no support for the hypothesis that topical tacrolimus increases long-term cancer risk in children with atopic dermatitis. |
|---|
| DOI: | doi:10.1016/j.jaad.2020.03.075 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jaad.2020.03.075 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0190962220304989 |
|---|
| | DOI: https://doi.org/10.1016/j.jaad.2020.03.075 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | atopic dermatitis |
|---|
| | cancer risk |
|---|
| | lymphoma |
|---|
| | skin cancer |
|---|
| | tacrolimus |
|---|
| | topical calcineurin inhibitors |
|---|
| K10plus-PPN: | 1737441926 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
No evidence of increased cancer incidence in children using topical tacrolimus for atopic dermatitis / Paller, Amy S. [VerfasserIn]; 1 April 2020 (Online-Ressource)
