Association between C reactive protein and microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes

• Verfasst von: Hayfron-Benjamin, Charles F. [VerfasserIn]
• Verfasst von: Zee, Anke H. Maitland-van der [VerfasserIn]
• Verfasst von: Born, Bert-Jan van den [VerfasserIn]
• Verfasst von: Amoah, Albert G. B. [VerfasserIn]
• Verfasst von: Meeks, Karlijn A. C. [VerfasserIn]
• Verfasst von: Klipstein-Grobusch, Kerstin [VerfasserIn]
• Verfasst von: Schulze, Matthias B. [VerfasserIn]
• Verfasst von: Spranger, Joachim [VerfasserIn]
• Verfasst von: Danquah, Ina [VerfasserIn]
• Verfasst von: Smeeth, Liam [VerfasserIn]
• Verfasst von: Beune, Erik J. A. J. [VerfasserIn]
• Verfasst von: Mockenhaupt, Frank [VerfasserIn]
• Verfasst von: Agyemang, Charles O. [VerfasserIn]
• Titel: Association between C reactive protein and microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes
• Titelzusatz: the RODAM study
• Verf.angabe: Charles Frederick Hayfron-Benjamin, Anke H. Maitland-van der Zee, Bert-Jan van den Born, Albert G.B. Amoah, Karlijn A.C. Meeks, Kerstin Klipstein-Grobusch, Matthias B. Schulze, Joachim Spranger, Ina Danquah, Liam Smeeth, Erik J.A.J. Beune, Frank Mockenhaupt, Charles O. Agyemang
• E-Jahr: 2020
• Jahr: July 14, 2020
• Umfang: 9 S.
• Teil: volume:8
• Teil: year:2020
• Teil: extent:9
• Fussnoten: Gesehen am 30.10.2020
• Titel Quelle: Enthalten in: BMJ Open Diabetes Research & Care
• Ort Quelle: London : BMJ Publishing Group, 2013
• Jahr Quelle: 2020
• Band/Heft Quelle: 8(2020) Artikel-Nummer e001235, 9 Seiten
• ISSN Quelle: 2052-4897
• DOI: doi:10.1136/bmjdrc-2020-001235
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: adult diabetes
• Sach-SW: C-reactive protein
• Sach-SW: inflammation
• Sach-SW: microvascular and macrovascular complications
• K10plus-PPN: 1737452529

Abstract

Introduction Although inflammation assessed by elevated C reactive protein (CRP) concentration is known to be associated with risk of cardiovascular disease, its association with microvascular and macrovascular dysfunction in diabetes and non-diabetes remains unclear. We examined the association between CRP and diabetes and associated microvascular and macrovascular dysfunction in sub-Saharan Africans with and without diabetes. - Research design and methods Cross-sectional analyses of baseline data from the multicenter RODAM study (Research on Obesity and Diabetes among African Migrants) including 5248 Ghanaians (583 with diabetes, 4665 without diabetes) aged 25-70 years were done. Logistic regression analyses were used to examine the associations between CRP Z-scores and diabetes and microvascular (nephropathy) and macrovascular (peripheral artery disease (PAD)) dysfunction, with adjustments for age, sex, site of residence, smoking, body mass index, systolic blood pressure, and low-density lipoprotein cholesterol. - Results In the fully adjusted models, higher CRP concentration was significantly associated with diabetes (adjusted OR 1.13; 95% CI 1.05 to 1.21, p=0.002). In participants with diabetes, higher CRP concentration was associated with PAD (1.19; 1.03 to 1.41, p=0.046) but not nephropathy (1.13; 0.97 to 1.31, p=0.120). Among participants without diabetes, higher CRP concentration was associated with higher odds of PAD (1.10; 1.01 to 1.21, p=0.029) and nephropathy (1.12; 1.04 to 1.22, p=0.004). - Conclusions In this study, higher CRP concentration was associated with higher odds of diabetes in sub-Saharan Africans. Also, higher CRP concentration was associated with higher odds of nephropathy and PAD in non-diabetes and higher odds of PAD in diabetes. CRP may be an important marker for assessment of risk of diabetes and risk for PAD and nephropathy in sub-Saharan Africans with and without diabetes.