Neurogenesis and depression

• Verfasst von: Henn, Fritz A. [VerfasserIn]
• Verfasst von: Vollmayr, Barbara [VerfasserIn]
• Titel: Neurogenesis and depression
• Titelzusatz: etiology or epiphenomenon?
• Verf.angabe: Fritz A. Henn, Barbara Vollmayr
• E-Jahr: 2004
• Jahr: 2004 Aug 1
• Umfang: 5 S.
• Fussnoten: Gesehen am 03.11.2020
• Titel Quelle: Enthalten in: Biological psychiatry
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1985
• Jahr Quelle: 2004
• Band/Heft Quelle: 56(2004), 3, Seite 146-150
• ISSN Quelle: 1873-2402
• DOI: doi:10.1016/j.biopsych.2004.04.011
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Animals
• Sach-SW: Antidepressive Agents
• Sach-SW: Brain
• Sach-SW: Cell Division
• Sach-SW: Depression
• Sach-SW: Disease Models, Animal
• Sach-SW: Humans
• Sach-SW: Neurons
• Sach-SW: Stress, Physiological
• Sach-SW: Time Factors
• K10plus-PPN: 1737590913

Abstract

The concept that decreased neurogenesis might be the cause of depression is supported by the effects of stress on neurogenesis and the demonstration that neurogenesis seems to be necessary for antidepressant action. Data from the animal models tested to date show that decreasing the rate of neurogenesis does not lead to depressive behavior. Furthermore, evidence shows that an effective treatment for depression, transcranial magnetic stimulation, does not alter rates of neurogenesis. On the basis of these findings, it is suggested that neurogenesis might play a subtle role in depression but that it is not the primary factor in the final common pathway leading to depression.