Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment

• Verfasst von: Sartorius, Alexander [VerfasserIn]
• Verfasst von: Vollmayr, Barbara [VerfasserIn]
• Verfasst von: Neumann-Haefelin, Claudia [VerfasserIn]
• Verfasst von: Ende, Gabriele [VerfasserIn]
• Verfasst von: Hoehn, Mathias [VerfasserIn]
• Verfasst von: Henn, Fritz A. [VerfasserIn]
• Titel: Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment
• Verf.angabe: Alexander Sartorius, Barbara Vollmayr, Claudia Neumann-Haefelin, Gabriele Ende, Mathias Hoehn, Fritz A. Henn
• E-Jahr: 2003
• Jahr: December 2nd, 2003
• Umfang: 3 S.
• Fussnoten: Gesehen am 03.11.2020
• Titel Quelle: Enthalten in: Neuroreport
• Ort Quelle: London : Lippincott Williams & Wilkins, 1990
• Jahr Quelle: 2003
• Band/Heft Quelle: 14(2003), 17, Seite 2199-2201
• ISSN Quelle: 1473-558X
• DOI: doi:10.1097/00001756-200312020-00013
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1737612143

Abstract

Metabolic changes in the hippocampus formation can be investigated with in vivo magnetic resonance spectroscopy (MRS). Learned helplessness (LH) is a well validated animal model of depression which we established in Sprague-Dawley rats defining some as “learned helpless” (LH) or not “learned helpless” (NLH). Helpless and non-helpless rats received a course of daily administered electroconvulsive shocks (ECS) for 6 days. MRS measurements were performed on a 4.7 T animal scanner with an average voxel size within the rat hippocampus of 10 μl. In LH rats hippocampal creatine/NAA rose significantly (14%) whereas creatine/NAA of NLH rats showed no increase at all. A possible connection between hippocampal creatine levels and major depressive disorders as a reflection of changes in energy metabolism is discussed.