| |  Online-Ressource |
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| Verfasst von: | Zink, Mathias [VerfasserIn]  |
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| | Otto, Christiane [VerfasserIn] |
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| | Zörner, Björn [VerfasserIn] |
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| | Zacher, Christiane [VerfasserIn] |
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| | Schütz, Günther [VerfasserIn] |
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| | Henn, Fritz A. [VerfasserIn] |
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| | Gass, Peter [VerfasserIn] |
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| Titel: | Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclase activating polypeptide type-I-receptor |
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| Verf.angabe: | Mathias Zink, Christiane Otto, Björn Zörner, Christiane Zacher, Günther Schütz, Fritz A. Henn, Peter Gass |
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| E-Jahr: | 2004 |
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| Jahr: | 9 April 2004 |
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| Umfang: | 3 S. |
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| Fussnoten: | Gesehen am 03.11.2020 |
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| Titel Quelle: | Enthalten in: Neuroscience letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 360(2004), 1, Seite 106-108 |
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| ISSN Quelle: | 1872-7972 |
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| Abstract: | In vitro pituitary adenylate cyclase activating polypeptide (PACAP) induces the expression of brain-derived neurotrophic factor (BDNF) via its specific receptor PAC1. Since BDNF has been implicated in learning paradigms and mice lacking functional PAC1 have deficits in hippocampus-dependent associative learning, we investigated whether PAC1 mutants show alterations in hippocampal expression of BDNF and its receptor TrkB. Semi-quantitative in situ-hybridization using exon-specific BDNF-probes revealed significantly reduced expression of the exon-III and exon-V-specific transcripts within the hippocampal CA3 region in PAC1-deficient mice. A similar trend was observed for the exon-I-specific transcript. The expression of the exon-III-specific transcript was also reduced within the dentate gyrus, while Trk B-expression did not differ between genotypes. Our data demonstrate that even in vivo PAC1-mediated signaling seems to play a pivotal role for the transcriptional regulation of BDNF. |
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| DOI: | doi:10.1016/j.neulet.2004.01.030 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neulet.2004.01.030 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0304394004000928 |
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| | DOI: https://doi.org/10.1016/j.neulet.2004.01.030 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Brain-derived neurotrophic factor |
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| | In situ-hybridization |
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| | PACAP-type-I-receptor |
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| | Pituitary adenylate cyclase activating polypeptide (PACAP) |
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| K10plus-PPN: | 1737614359 |
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| Verknüpfungen: | → Zeitschrift |
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Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclase activating polypeptide type-I-receptor / Zink, Mathias [VerfasserIn]; 9 April 2004 (Online-Ressource)
