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Verfasst von:Chojowski, Robert [VerfasserIn]   i
 Schwarz, Ulrich S. [VerfasserIn]   i
 Ziebert, Falko [VerfasserIn]   i
Titel:Reversible elastic phase field approach and application to cell monolayers
Verf.angabe:Robert Chojowski, Ulrich S. Schwarz, and Falko Ziebert
E-Jahr:2020
Jahr:1 October 2020
Fussnoten:Gesehen am 03.11.2020
Titel Quelle:Enthalten in: The European physical journal / E
Ort Quelle:Berlin : Springer, 2000
Jahr Quelle:2020
Band/Heft Quelle:43(2020) Artikel-Nummer 63, 12 Seiten
ISSN Quelle:1292-895X
Abstract:Motion and generation of forces by single cells and cell collectives are essential elements of many biological processes, including development, wound healing and cancer cell migration. Quantitative wound healing assays have demonstrated that cell monolayers can be both dynamic and elastic at the same time. However, it is very challenging to model this combination with conventional approaches. Here we introduce an elastic phase field approach that allows us to predict the dynamics of elastic sheets under the action of active stresses and localized forces, e.g. from leader cells. Our method ensures elastic reversibility after release of forces. We demonstrate its potential by studying several paradigmatic situations and geometries relevant for single cells and cell monolayers, including elastic bars, contractile discs and expanding monolayers with leader cells.
DOI:doi:10.1140/epje/i2020-11988-1
URL:kostenfrei: Volltext: https://doi.org/10.1140/epje/i2020-11988-1
 DOI: https://doi.org/10.1140/epje/i2020-11988-1
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1737645149
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