| |  Online-Ressource |
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| Verfasst von: | Leonardi-Essmann, Fernando [VerfasserIn]  |
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| | Emig, Michael [VerfasserIn] |
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| | Kitamura, Yoshihisa [VerfasserIn] |
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| | Spanagel, Rainer [VerfasserIn] |
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| | Gebicke-Härter, Peter J. [VerfasserIn] |
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| Titel: | Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia |
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| Verf.angabe: | Fernando Leonardi-Essmann, Michael Emig, Yoshihisa Kitamura, Rainer Spanagel, Peter J. Gebicke-Haerter |
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| E-Jahr: | 2005 |
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| Jahr: | 28 January 2005 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 03.11.2020 |
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| Titel Quelle: | Enthalten in: Journal of neuroimmunology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1981 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 160(2005), 1, Seite 92-101 |
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| ISSN Quelle: | 1872-8421 |
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| Abstract: | Fractalkine is the only known member of the CX3C-chemokine family, and so is its receptor CX3CR1. Fractalkine, typically is expressed by neurons where it is inserted in the plasma membrane (“chemokine on a stalk”). It can, however, be clipped off by a specific enzyme and diffuse into the extracellular space. CX3CR1 is primarily expressed by microglia, the phagocytes of the brain. This study was aimed at studying gene expression changes in cultured rat microglia upon fractalkine stimulation using gene chip technology. Six genes turned out to be upregulated, amongst which milk-fat globule EGF factor-8 protein (MFG-E8) was the most surprising, but also the most revealing one. We hypothesize that it serves as a bridging molecule between apoptotic cells (neurons) and microglia. Since the docking to microglia is, in part, mediated by members of the integrin family, six of these molecules have been-post hoc-included in real-time PCR confirmations of chip results. Two of them-integrin α2 and integrin β5-were upregulated as well. These data provide a much closer look into molecular mechanisms involved in apoptosis of neurons and their removal by microglia. |
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| DOI: | doi:10.1016/j.jneuroim.2004.11.012 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jneuroim.2004.11.012 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0165572804004151 |
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| | DOI: https://doi.org/10.1016/j.jneuroim.2004.11.012 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Fractalkine |
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| | Integrins |
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| | Microarrays |
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| | Microglia |
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| | Milk-fat globule EGF factor-8 protein |
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| K10plus-PPN: | 1737684500 |
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| Verknüpfungen: | → Zeitschrift |
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Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia / Leonardi-Essmann, Fernando [VerfasserIn]; 28 January 2005 (Online-Ressource)
