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Status: Bibliographieeintrag

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Verfasst von:Krummradt, Felix [VerfasserIn]   i
 Sauer, Sandra [VerfasserIn]   i
 Pavel, Petra [VerfasserIn]   i
 Klein, Eva-Maria [VerfasserIn]   i
 Schmitt, Anita [VerfasserIn]   i
 Kriegsmann, Mark [VerfasserIn]   i
 Jordan, Karin [VerfasserIn]   i
 Müller-Tidow, Carsten [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Wuchter, Patrick [VerfasserIn]   i
 Kriegsmann, Katharina [VerfasserIn]   i
Titel:Storage, utilization, and disposal of hematopoietic stem cell products in patients with multiple myeloma
Verf.angabe:Felix Krummradt, Sandra Sauer, Petra Pavel, Eva-Maria Klein, Anita Schmitt, Mark Kriegsmann, Karin Jordan, Carsten Müller-Tidow, Hartmut Goldschmidt, Patrick Wuchter, Katharina Kriegsmann
E-Jahr:2020
Jahr:16 May 2020
Umfang:8 S.
Fussnoten:Gesehen am 04.11.2020
Titel Quelle:Enthalten in: Biology of blood and marrow transplantation
Ort Quelle:[Erscheinungsort nicht ermittelbar] : Elsevier Health Sciences, 1998
Jahr Quelle:2020
Band/Heft Quelle:26(2020), 9, Seite 1589-1596
ISSN Quelle:1523-6536
Abstract:High-dose chemotherapy (HD-CHT) and autologous blood stem cell transplantation (ABSCT) represent the standard of care in multiple myeloma (MM) for transplantation-eligible patients. Up to 3 HD-CHT/ABSCT treatments may be administered during the course of disease, including during late-onset relapse. Transplantation centers routinely collect more than 1 peripheral blood stem cell (PBSC) graft; however, subsequent HD-CHT/ABSCT treatments are often not performed, for various reasons. Currently, little is known about the actual utilization rate of stored PBSCs. The collection, storage, and disposal of PBSC products was analyzed in a large cohort of patients with MM (n = 1114) over a 12-year period with a minimum follow-up of 6 years. The final dataset analysis was performed in March 2019, which was set as the reference date. Based on institution-specific charges, the costs for PBSC collection, processing, and storage were estimated. The median number of sufficient PBSC transplantations per patient was 3 (range, 0 to 6), which were stored in a median of 3 (range, 1 to 11) cryopreserved bags (overall, n = 3644). A total of 95% of all patients (n = 1059) underwent at least 1 HD-CHT/ABSCT treatment. However, multiple ABSCTs were performed in 51% of the patients (n2/3 ABSCTs = 538), and only 14% of the patients underwent ABSCT 3 times (n3 ABSCTs = 149). Only a small proportion of collected PBSC bags (5%; n = 109) were used after being stored for longer than 5 years. Overall, 23% of the products (n = 830) were discarded, and 16% (n = 566) were kept in storage until the reference date. From a retrospective standpoint, the collected and discarded (definitively not used) or stored (potentially not used) cryostored PBSCs were associated with considerable costs for long-term cryostorage of approximately €1,600,000. We identified considerable discrepancies between the collection/storage and utilization of PBSCs. This is associated with significant efforts and costs on the one hand; on the other hand, disposal may raise legal and ethical questions. Therefore, we implemented comprehensive guidelines for the systematic reevaluation of stored PBSC grafts at our institution.
DOI:doi:10.1016/j.bbmt.2020.04.030
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.bbmt.2020.04.030
 Volltext: http://www.sciencedirect.com/science/article/pii/S1083879120302858
 DOI: https://doi.org/10.1016/j.bbmt.2020.04.030
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Autologous transplantation
 Cost evaluation
 Cryostorage
 Hematopoietic stem cell products
 Multiple myeloma
 Peripheral blood stem cells
K10plus-PPN:1737755351
Verknüpfungen:→ Zeitschrift

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