Adverse effects in the fish embryo acute toxicity (FET) test

• Verfasst von: Hellfeld, Rebecca von [VerfasserIn]
• Verfasst von: Brotzmann, Katharina [VerfasserIn]
• Verfasst von: Baumann, Lisa [VerfasserIn]
• Verfasst von: Strecker, Ruben [VerfasserIn]
• Verfasst von: Braunbeck, Thomas [VerfasserIn]
• Titel: Adverse effects in the fish embryo acute toxicity (FET) test
• Titelzusatz: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos
• Verf.angabe: Rebecca von Hellfeld, Katharina Brotzmann, Lisa Baumann, Ruben Strecker and Thomas Braunbeck
• E-Jahr: 2020
• Jahr: 29 September 2020
• Fussnoten: Gesehen am 04.11.2020
• Titel Quelle: Enthalten in: Environmental sciences Europe
• Ort Quelle: Berlin : Springer, 2011
• Jahr Quelle: 2020
• Band/Heft Quelle: 32(2020) Artikel-Nummer 122, 18 Seiten
• ISSN Quelle: 2190-4715
• DOI: doi:10.1186/s12302-020-00398-3
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1737755947
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

The Fish Embryo Acute Toxicity (FET) test with the zebrafish (Danio rerio) embryo, the OECD test guideline (TG) 236, has been designed as an alternative for acute fish toxicity testing such as the OECD Acute Fish Toxicity Test (TG 203). To provide equivalent sensitivity to the acute fish test, the original FET test was designed to use only four morphological core endpoints: coagulation of the embryo, lack of somite formation, lack of heart beat, and non-detachment of the tail. These endpoints were selected due to (1) their association with mortality, directly or indirectly, (2) improve the practicality for screening by well-trained technical staff, and (3) the endpoints being relatively simple morphological alterations.