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Verfasst von:Colla, Michael [VerfasserIn]   i
 Ende, Gabriele [VerfasserIn]   i
 Bohrer, Markus [VerfasserIn]   i
 Deuschle, Michael [VerfasserIn]   i
 Kronenberg, Golo D. [VerfasserIn]   i
 Henn, Fritz A. [VerfasserIn]   i
 Heuser, Isabella [VerfasserIn]   i
Titel:MR spectroscopy in Alzheimer’s disease
Titelzusatz:gender differences in probabilistic learning capacity
Verf.angabe:Michael Colla, Gabriele Ende, Markus Bohrer, Michael Deuschle, Golo Kronenberg, Fritz Henn, Isabella Heuser
E-Jahr:2003
Jahr:28 January 2003
Umfang:8 S.
Fussnoten:Gesehen am 05.11.2020
Titel Quelle:Enthalten in: Neurobiology of aging
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1980
Jahr Quelle:2003
Band/Heft Quelle:24(2003), 4, Seite 545-552
ISSN Quelle:1558-1497
Abstract:Degenerative alterations of cortical and subcortical regions in Alzheimer disease (AD) can be estimated by the extent of brain metabolite changes as measured by magnetic resonance spectroscopic imaging (MRSI). A neuropsychological assessment may correlate with metabolite levels and could evaluate underlying degenerative processes. Probabilistic-related classification learning, which represents one form of procedural learning, is associated with the neostriatum. The present study was aimed at examining the correlation of spectroscopic imaging in subcortical regions with the evaluation of specific neuropsychological findings. Twenty-two patients with Alzheimer’s disease were compared to 15 healthy elderly control subjects. Proton MRSI of the basal ganglia (BG) and thalamus region was performed for detection of N-acetylaspartate (NAA), trimethylamine (TMA) and creatine ((P)Cr). In addition, a probabilistic-related classification learning task (Weather Prediction Task (WT)) was applied. We observed that in patients a high TMA signal in the basal ganglia region was correlated with a poorer performance in the probabilistic learning task (Spearman rank order correlation (SROC)=−0.6, P<0.009). Although Alzheimer’s patients, as a group, did not differ from controls with regard to probabilistic learning capacity (PLC), male AD patients, as compared to male controls, displayed an impairment in the task performance by 28% (P<0.03) and showed a 16% elevation in TMA signaling (P<0.04). The altered metabolite signals and ratios in combination with the cognitive performance might suggest gender-related neuronal degeneration and dysfunction within subcortical regions in AD.
DOI:doi:10.1016/S0197-4580(02)00189-6
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/S0197-4580(02)00189-6
 Volltext: http://www.sciencedirect.com/science/article/pii/S0197458002001896
 DOI: https://doi.org/10.1016/S0197-4580(02)00189-6
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:-acetylaspartate
 Alzheimer disease
 Basal ganglia
 Gender-related degeneration
 Implicit memory
 Magnetic resonance imaging
 Magnetic resonance spectroscopy
 Probabilistic learning
 Striatum
 Trimethylamine
K10plus-PPN:1737975300
Verknüpfungen:→ Zeitschrift

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