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Verfasst von:Al Said, Samer [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
 Alabed, Samer [VerfasserIn]   i
Titel:Cochrane corner
Titelzusatz:NOACs in atrial fibrillation patients post-percutaneous coronary intervention
Verf.angabe:Samer Al Said, Hugo A. Katus, Samer Alabed
E-Jahr:2020
Jahr:May 29, 2020
Umfang:3 S.
Fussnoten:Gesehen am 05.11.2020
Titel Quelle:Enthalten in: Heart
Ort Quelle:[London] : BMJ Publ. Group, 1996
Jahr Quelle:2020
Band/Heft Quelle:106(2020), 17, Seite 1293-1295
ISSN Quelle:1468-201X
Abstract:One in ten people undergoing percutaneous coronary intervention (PCI) has underlying atrial fibrillation (AF). They are often treated with long-term oral anticoagulation for stroke prevention and are commenced on antiplatelet therapy post-PCI to prevent stent thrombosis.1 A careful balance of risk of bleeding versus thrombosis is essential. - - Options for oral anticoagulation include vitamin K antagonists (VKAs), for example, warfarin, and non‐vitamin K antagonist oral anticoagulants (NOACs), also referred to as direct oral anticoagulants. In contrast to VKA, NOACs directly inhibit either thrombin (dabigatran) or factor X (rivaroxaban, apixaban and edoxaban). Recent randomised controlled trials (RCTs) have compared NOACs with warfarin in patients with AF undergoing PCI. We reviewed these RCTs to summarise their efficacy and safety results.2 One of our aims was also to compare NOACs with each other; however, no RCT conducted such a comparison. We, therefore, performed a network meta-analysis to compare NOACs indirectly. A network meta-analysis is a unique statistical technique that facilitates indirect comparisons of interventions based on a common comparator across trials, that is, warfarin, in our analysis (figure 1). - - - - Figure 1 - Network diagram for major bleeding. Nodes are weighted according to the number of studies that includes the respective intervention. Edges are weighted according to the number of patients included in the respective comparison. Numbers on the lines represent the number of trials …
DOI:doi:10.1136/heartjnl-2020-316726
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1136/heartjnl-2020-316726
 Volltext: https://heart.bmj.com/content/early/2020/05/29/heartjnl-2020-316726
 DOI: https://doi.org/10.1136/heartjnl-2020-316726
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1737997096
Verknüpfungen:→ Zeitschrift

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