| |  Online-Ressource |
|---|
| Verfasst von: | Goyal, Manu Jain [VerfasserIn]  |
|---|
| | Zhao, Xiyan [VerfasserIn] |
|---|
| | Bozhinova, Mariya [VerfasserIn] |
|---|
| | Andrade-López, Karla [VerfasserIn] |
|---|
| | Heus, Cecilia de [VerfasserIn] |
|---|
| | Schulze-Dramac, Sandra [VerfasserIn] |
|---|
| | Müller-McNicoll, Michaela [VerfasserIn] |
|---|
| | Klumperman, Judith [VerfasserIn] |
|---|
| | Béthune, Julien [VerfasserIn] |
|---|
| Titel: | A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells |
|---|
| Verf.angabe: | Manu Jain Goyal, Xiyan Zhao, Mariya Bozhinova, Karla Andrade-López, Cecilia de Heus, Sandra Schulze-Dramac, Michaela Müller-McNicoll, Judith Klumperman, Julien Béthune |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 14 July 2020 |
|---|
| Teil: | volume:3 |
|---|
| | year:2020 |
|---|
| | number:9 |
|---|
| Fussnoten: | Gesehen am 09.11.2020 |
|---|
| Titel Quelle: | Enthalten in: Life science alliance |
|---|
| Ort Quelle: | Heidelberg : EMBO Press, 2018 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 3(2020,9) Artikel-Nummer e02000714, 15 Seiten |
|---|
| ISSN Quelle: | 2575-1077 |
|---|
| Abstract: | Coat protein complex I (COPI)-coated vesicles mediate membrane trafficking between Golgi cisternae as well as retrieval of proteins from the Golgi to the endoplasmic reticulum. There are several flavors of the COPI coat defined by paralogous subunits of the protein complex coatomer. However, whether paralogous COPI proteins have specific functions is currently unknown. Here, we show that the paralogous coatomer subunits γ1-COP and γ2-COP are differentially expressed during the neuronal differentiation of mouse pluripotent cells. Moreover, through a combination of genome editing experiments, we demonstrate that whereas γ-COP paralogs are largely functionally redundant, γ1-COP specifically promotes neurite outgrowth. Our work stresses a role of the COPI pathway in neuronal polarization and provides evidence for distinct functions for coatomer paralogous subunits in this process. |
|---|
| DOI: | doi:10.26508/lsa.202000714 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.26508/lsa.202000714 |
|---|
| | Volltext: https://www.life-science-alliance.org/content/3/9/e202000714 |
|---|
| | DOI: https://doi.org/10.26508/lsa.202000714 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1738241165 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬A¬ paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells / Goyal, Manu Jain [VerfasserIn]; 14 July 2020 (Online-Ressource)
