Status: Bibliographieeintrag
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| Verfasst von: | Kölsch, Heike [VerfasserIn]  |
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| | Jessen, F. [VerfasserIn] |
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| | Freymann, N. [VerfasserIn] |
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| | Kreis, Markus [VerfasserIn] |
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| | Hentschel, Frank [VerfasserIn] |
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| | Maier, W. [VerfasserIn] |
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| | Heun, R. [VerfasserIn] |
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| Titel: | ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia |
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| Verf.angabe: | H. Kölsch, F. Jessen, N. Freymann, M. Kreis, F. Hentschel, W. Maier, R. Heun |
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| Jahr: | 2005 |
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| Jahr des Originals: | 2004 |
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| Umfang: | 3 S. |
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| Fussnoten: | Available online 10 December 2004 ; Gesehen am 10.11.2020 |
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| Titel Quelle: | Enthalten in: Neuroscience letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 377(2005), 1, Seite 37-39 |
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| ISSN Quelle: | 1872-7972 |
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| Abstract: | Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD. |
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| DOI: | doi:10.1016/j.neulet.2004.11.062 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neulet.2004.11.062 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0304394004014776 |
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| | DOI: https://doi.org/10.1016/j.neulet.2004.11.062 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alzheimer's disease |
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| | Angiotensin converting enzyme |
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| | Association |
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| | Polymorphism |
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| | Vascular dementia |
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| K10plus-PPN: | 1738306720 |
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| Verknüpfungen: | → Zeitschrift |
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ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia / Kölsch, Heike [VerfasserIn]; 2005 (Online-Ressource)
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