| |  Online-Ressource |
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| Verfasst von: | Trares, Kira [VerfasserIn]  |
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| | Gào, Xīn [VerfasserIn] |
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| | Perna, Laura [VerfasserIn] |
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| | Rujescu, Dan [VerfasserIn] |
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| | Stocker, Hannah [VerfasserIn] |
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| | Möllers, Tobias [VerfasserIn] |
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| | Beyreuther, Konrad [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| | Schöttker, Ben [VerfasserIn] |
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| Titel: | Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence |
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| Titelzusatz: | results from a prospective cohort study |
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| Verf.angabe: | Kira Trares, Xīn Gào, Laura Perna, Dan Rujescu, Hannah Stocker, Tobias Möllers, Konrad Beyreuther, Hermann Brenner, Ben Schöttker |
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| E-Jahr: | 2020 |
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| Jahr: | 12 April 2020 |
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| Umfang: | 10 S. |
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| Fussnoten: | Im Titel ist "2α" tiefgestellt ; Gesehen am 10.11.2020 |
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| Titel Quelle: | Enthalten in: Alzheimer's and dementia |
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| Ort Quelle: | Hoboken, NJ : Wiley, 2005 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 16(2020), 5, Seite 804-813 |
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| ISSN Quelle: | 1552-5279 |
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| Abstract: | Introduction Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, a biomarker of lipid peroxidation, with dementia are limited. Methods Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort. Results Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF2α tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8-iso-PGF2α levels were statistically significantly associated with all-cause dementia and AD incidence. Discussion Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk. |
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| DOI: | doi:10.1002/alz.12081 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/https://doi.org/10.1002/alz.12081 |
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| | Volltext: https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.12081 |
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| | DOI: https://doi.org/10.1002/alz.12081 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 8-iso-prostaglandin F2α |
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| | Alzheimer's disease |
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| | cohort study |
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| | dementia |
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| | oxidative stress |
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| | vascular dementia |
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| K10plus-PPN: | 1738318966 |
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| Verknüpfungen: | → Zeitschrift |
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Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence / Trares, Kira [VerfasserIn]; 12 April 2020 (Online-Ressource)
