Gene-based immunotherapy of skin cancers

• Verfasst von: Sun, Yuansheng [VerfasserIn]
• Verfasst von: Schadendorf, Dirk [VerfasserIn]
• Titel: Gene-based immunotherapy of skin cancers
• Verf.angabe: Yuansheng Sun, Dirk Schadendorf
• Jahr: 2002
• Umfang: 15 S.
• Fussnoten: Gesehen am 11.11.2020
• Titel Quelle: Enthalten in: Dummer, Reinhard, 1960 - Cancers of the Skin
• Ort Quelle: Berlin : Springer, 2002
• Jahr Quelle: 2002
• Band/Heft Quelle: (2002), Seite 170-184
• ISBN Quelle: 978-3-642-59410-6
• DOI: doi:10.1007/978-3-642-59410-6_21
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1738434788

Abstract

Skin cancers continue to present a major therapeutic challenge to physicians. Recent advances in molecular genetics and improved understanding of immune responses to tumors have generated an interest in using gene-based immunotherapy for treating these malignancies. Two major forms of gene-based immunotherapy are currently being investigated. One focuses on genetic modification of some target cell populations of the host using immunostimulatory genes such as cytokines, in order to improve tumor immunogenicity and antitumor responses; the other is genetic immunization with the genes coding for melanoma-associated antigens recognized by cytotoxic T cells. This paper reviews these novel strategies and summarizes the most recent data recorded in either experimental studies or clinical trials.