Neurobiology of affective disorders

• Verfasst von: Henn, Fritz A. [VerfasserIn]
• Titel: Neurobiology of affective disorders
• Verf.angabe: F. Henn
• Jahr: 2001
• Umfang: 11 S.
• Fussnoten: Gesehen am 12.11.2020
• Titel Quelle: Enthalten in: Henn, Fritz A., 1941 - Contemporary psychiatry
• Ort Quelle: Berlin, Heidelberg : Springer Berlin Heidelberg, 2001
• Jahr Quelle: 2001
• Band/Heft Quelle: (2001), Seite 1637-1647
• ISBN Quelle: 978-3-642-59519-6
• DOI: doi:10.1007/978-3-642-59519-6_103
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Affective Disorder
• Sach-SW: Chronic Mild Stress
• Sach-SW: Depressed Patient
• Sach-SW: Depressive Illness
• Sach-SW: Suicide Victim
• K10plus-PPN: 1738543455

Abstract

The initial evolution of a biological explanation of mood and mood disorders came from accidental observations in internal medicine. Two observations resulted in the initial framing of the catecholamine hypothesis of affective disorders. The first came about when iproniazid was introduced for the treatment of tuberculosis. Patients at that time were sent to large sanatoriums and the initial trials of iproniazid were therefore carried out in these large clinic settings. It was noticed that patients on the new medication had pronounced mood elevation with increased sexual interest and had a picture which was essentially hypomanic. It was soon established that iproniazid was a monoamine oxidase inhibitor (MAOI) and could be expected to raise amine levels. The second observation was made in the treatment of hypertension. Reserpine was used in the 1950s and 1960s as the major drug in treating hypertension. Internists noted that up to 20% of the patients treated with reserpine developed severe depressions, and several suicides were reported.