| Online-Ressource |
Verfasst von: | Bali, Kiran Kumar [VerfasserIn]  |
| Selvaraj, Deepitha [VerfasserIn]  |
| Satagopam, Venkata* [VerfasserIn]  |
| Lu, Jianning [VerfasserIn]  |
| Schneider, Reinhard [VerfasserIn]  |
| Kuner, Rohini [VerfasserIn]  |
Titel: | Genome-wide identification and functional analyses of microRNA signatures associated with cancer pain |
Verf.angabe: | Kiran Kumar Bali, Deepitha Selvaraj, Venkata P. Satagopam, Jianning Lu, Reinhard Schneider, Rohini Kuner |
E-Jahr: | 2013 |
Jahr: | 18 October 2013 |
Umfang: | 19 S. |
Fussnoten: | Gesehen am 13.11.2020 |
Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine |
Ort Quelle: | Weinheim : Wiley-VCH, 2009 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 5(2013), 11, Seite 1740-1758 |
ISSN Quelle: | 1757-4684 |
Abstract: | Cancer pain remains a major challenge and there is an urgent demand for the development of specific mechanism-based therapies. Various diseases are associated with unique signatures of expression of microRNAs (miRNAs), which reveal deep insights into disease pathology. Using a comprehensive approach combining genome-wide miRNA screening, molecular and in silico analyses with behavioural approaches in a clinically relevant model of metastatic bone-cancer pain in mice, we now show that tumour-induced conditions are associated with a marked dysregulation of 57 miRNAs in sensory neurons corresponding to tumour-affected areas. By establishing protocols for interference with disease-induced miRNA dysregulation in peripheral sensory neurons in vivo, we functionally validate six dysregulated miRNAs as significant modulators of tumour-associated hypersensitivity. In silico analyses revealed that their predicted targets include key pain-related genes and we identified Clcn3, a gene encoding a chloride channel, as a key miRNA target in sensory neurons, which is functionally important in tumour-induced nociceptive hypersensitivity in vivo. Our results provide new insights into endogenous gene regulatory mechanisms in cancer pain and open up attractive and viable therapeutic options. |
DOI: | doi:10.1002/emmm.201302797 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/emmm.201302797 |
| Volltext: https://www.embopress.org/doi/full/10.1002/emmm.201302797 |
| DOI: https://doi.org/10.1002/emmm.201302797 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | bone metastatic pain |
| Clcn3 |
| gene regulation |
| miRNA inhibitors |
| miRNA mimics |
K10plus-PPN: | 1738657787 |
Verknüpfungen: | → Zeitschrift |
Genome-wide identification and functional analyses of microRNA signatures associated with cancer pain / Bali, Kiran Kumar [VerfasserIn]; 18 October 2013 (Online-Ressource)