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Status: Bibliographieeintrag

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Verfasst von:Bali, Kiran Kumar [VerfasserIn]   i
 Selvaraj, Deepitha [VerfasserIn]   i
 Satagopam, Venkata* [VerfasserIn]   i
 Lu, Jianning [VerfasserIn]   i
 Schneider, Reinhard [VerfasserIn]   i
 Kuner, Rohini [VerfasserIn]   i
Titel:Genome-wide identification and functional analyses of microRNA signatures associated with cancer pain
Verf.angabe:Kiran Kumar Bali, Deepitha Selvaraj, Venkata P. Satagopam, Jianning Lu, Reinhard Schneider, Rohini Kuner
E-Jahr:2013
Jahr:18 October 2013
Umfang:19 S.
Fussnoten:Gesehen am 13.11.2020
Titel Quelle:Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine
Ort Quelle:Weinheim : Wiley-VCH, 2009
Jahr Quelle:2013
Band/Heft Quelle:5(2013), 11, Seite 1740-1758
ISSN Quelle:1757-4684
Abstract:Cancer pain remains a major challenge and there is an urgent demand for the development of specific mechanism-based therapies. Various diseases are associated with unique signatures of expression of microRNAs (miRNAs), which reveal deep insights into disease pathology. Using a comprehensive approach combining genome-wide miRNA screening, molecular and in silico analyses with behavioural approaches in a clinically relevant model of metastatic bone-cancer pain in mice, we now show that tumour-induced conditions are associated with a marked dysregulation of 57 miRNAs in sensory neurons corresponding to tumour-affected areas. By establishing protocols for interference with disease-induced miRNA dysregulation in peripheral sensory neurons in vivo, we functionally validate six dysregulated miRNAs as significant modulators of tumour-associated hypersensitivity. In silico analyses revealed that their predicted targets include key pain-related genes and we identified Clcn3, a gene encoding a chloride channel, as a key miRNA target in sensory neurons, which is functionally important in tumour-induced nociceptive hypersensitivity in vivo. Our results provide new insights into endogenous gene regulatory mechanisms in cancer pain and open up attractive and viable therapeutic options.
DOI:doi:10.1002/emmm.201302797
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/emmm.201302797
 Volltext: https://www.embopress.org/doi/full/10.1002/emmm.201302797
 DOI: https://doi.org/10.1002/emmm.201302797
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:bone metastatic pain
 Clcn3
 gene regulation
 miRNA inhibitors
 miRNA mimics
K10plus-PPN:1738657787
Verknüpfungen:→ Zeitschrift

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